UBA7 Antikörper

Produktnummer ABIN967228

Dieser Maus Monoklonal Antikörper detektiert spezifisch UBA7 in WB und ELISA. Es zeigt Reaktivität gegenüber Proben von Human. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für UBA7 Antikörper (ABIN967228)

Target: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser UBA7 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Klon: 5B10

Produktdetails anti-UBA7 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human UBE1L expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-UBA7 Antikörper (ABIN967228)

Kitareewan, Pitha-Rowe, Sekula, Lowrey, Nemeth, Golub, Freemantle, Dmitrovsky: "UBE1L is a retinoid target that triggers PML/RARalpha degradation and apoptosis in acute promyelocytic leukemia." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 99, Issue 6, pp. 3806-11, (2002) (PubMed).

Carritt, Kok, van den Berg, Osinga, Pilz, Hofstra, Davis, van der Veen, Rabbitts, Gulati: "A gene from human chromosome region 3p21 with reduced expression in small cell lung cancer." in: Cancer research, Vol. 52, Issue 6, pp. 1536-41, (1992) (PubMed).

Details zu UBA7

Target: UBA7 (Ubiquitin-Like Modifier Activating Enzyme 7 (UBA7))

Andere Bezeichnung: UBE1L

Hintergrund: The modification of proteins with ubiquitin is an important cellular mechanism for targeting.
Tissue specificity: Expressed in a variety of normal and tumor cell types, but is reduced in lung cancer cell lines abnormal or short-lived proteins for degradation. Ubiquitination involves at least three classes of enzymes: ubiquitin-activating enzymes, or E1s, ubiquitin-conjugating enzymes, or E2s, and ubiquitin-protein ligases, or E3s. This gene encodes a member of the E1 ubiquitin-activating enzyme family. The encoded enzyme is a retinoid target that triggers promyelocytic leukemia (PML)/retinoic acid receptor alpha (RARalpha) degradation and apoptosis in acute promyelocytic leukemia, where it is involved in the conjugation of the ubiquitin-like interferonstimulated gene 15 protein.
Synonyms: D8, UBE2, UBA1B, UBE1L, MGC12713, UBA7

Molekulargewicht: 112kDa

Gen-ID: 7318