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SMAD1 Antikörper (C-Term)

Dieses Anti-SMAD1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von SMAD1 in WB. Geeignet für Human. Dieses Primary Antibody wurde in 1 Publikation zitiert.
Produktnummer ABIN967044

Kurzübersicht für SMAD1 Antikörper (C-Term) (ABIN967044)

Target

Alle SMAD1 Antikörper anzeigen
SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

Reaktivität

  • 198
  • 122
  • 95
  • 10
  • 8
  • 7
  • 6
  • 6
  • 6
  • 6
  • 6
  • 5
  • 4
  • 4
  • 3
  • 3
  • 1
Human

Wirt

  • 208
  • 19
Kaninchen

Klonalität

  • 199
  • 29
Polyklonal

Konjugat

  • 114
  • 18
  • 13
  • 7
  • 5
  • 5
  • 5
  • 5
  • 5
  • 5
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 4
  • 1
  • 1
Dieser SMAD1 Antikörper ist unkonjugiert

Applikation

  • 182
  • 82
  • 59
  • 53
  • 52
  • 32
  • 28
  • 27
  • 24
  • 12
  • 6
  • 4
  • 4
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 24
    • 24
    • 24
    • 15
    • 9
    • 8
    • 8
    • 8
    • 7
    • 6
    • 6
    • 5
    • 5
    • 5
    • 5
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    C-Term

    Kreuzreaktivität

    Maus, Ratte (Rattus)

    Kreuzreaktivität (Details)

    No cross reactivity with other proteins.

    Produktmerkmale

    Rabbit IgG polyclonal antibody for Mothers against decapentaplegic homolog 1 (SMAD1) detection. Tested with WB in Human, Mouse, Rat.

    Immunogen

    A synthetic peptide corresponding to a sequence at the C-terminal of human Smad 1,2,3,5, identical to the related mouse and rat sequences.< br/>Immunogen was affinity purified.

    Isotyp

    IgG
  • Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Lyophilized

    Rekonstitution

    Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

    Buffer

    Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

    Konservierungsmittel

    Sodium azide, Thimerosal (Merthiolate)

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.
  • Zhu, Kavsak, Abdollah, Wrana, Thomsen: "A SMAD ubiquitin ligase targets the BMP pathway and affects embryonic pattern formation." in: Nature, Vol. 400, Issue 6745, pp. 687-93, (1999) (PubMed).

  • Target

    SMAD1 (SMAD, Mothers Against DPP Homolog 1 (SMAD1))

    Andere Bezeichnung

    Mothers against decapentaplegic homolog 1(MAD homolog 1/Mothers against DPP homolog 1)

    Hintergrund

    SMADs are proteins that modulate the activity of transforming growth factor beta ligands. The SMADs, often in complex with other SMADs/CoSMAD, act as transcription factors that regulate the expression of certain genes. Zhu, H et al concluded that targeted ubiquitination of SMADs may serve to control both embryonic development and a wide variety of cellular responses to TGF-beta signals. R-Smads or receptor regulated Smads are a class of proteins that include SMAD1, SMAD2, SMAD3, SMAD5, and SMAD8. In response to signals by the TGF-beta superfamily of ligands these proteins associate with receptor kinases and are phosphorylated at an SSXS motif at their extreme C-terminus. These proteins then typically bind to the common mediator Smad or co-SMAD SMAD4.

    Pathways

    Stem Cell Maintenance, Regulation of Muscle Cell Differentiation, Skeletal Muscle Fiber Development
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