RAD51 Antikörper (Isoform 2)

Produktnummer ABIN966939

Dieses Anti-RAD51-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von RAD51 in IHC. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 4+ Publikationen zitiert.

Kurzübersicht für RAD51 Antikörper (Isoform 2) (ABIN966939)

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD51 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-RAD51 Antikörper

Bindungsspezifität: Isoform 2

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human RAD51 homolog protein isoform 2

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-RAD51 Antikörper (ABIN966939)

Liang, Caporaso, McMaster, Ng, Landgren, Yeager, Chanock, Goldin: "Common genetic variants in candidate genes and risk of familial lymphoid malignancies." in: British journal of haematology, Vol. 146, Issue 4, pp. 418-23, (2009) (PubMed).

Rebbeck, Mitra, Domchek, Wan, Chuai, Friebel, Panossian, Spurdle, Chenevix-Trench, , Singer, Pfeiler, Neuhausen, Lynch, Garber, Weitzel, Isaacs, Couch, Narod, Rubinstein, Tomlinson, Ganz, Olopade, Tung, Blum, Greenberg, Nathanson, Daly: "Modification of ovarian cancer risk by BRCA1/2-interacting genes in a multicenter cohort of BRCA1/2 mutation carriers." in: Cancer research, Vol. 69, Issue 14, pp. 5801-10, (2009) (PubMed).

Kovalenko, Plug, Haaf, Gonda, Ashley, Ward, Radding, Golub: "Mammalian ubiquitin-conjugating enzyme Ubc9 interacts with Rad51 recombination protein and localizes in synaptonemal complexes." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 93, Issue 7, pp. 2958-63, (1996) (PubMed).

Benson, Stasiak, West: "Purification and characterization of the human Rad51 protein, an analogue of E. coli RecA." in: The EMBO journal, Vol. 13, Issue 23, pp. 5764-71, (1995) (PubMed).

Details zu RAD51

Target: RAD51 (DNA Repair Protein Homolog 1 (RAD51))

Andere Bezeichnung: RAD51 homolog protein

Hintergrund: RAD51 homolog protein isoform 2 is a member of the RAD51 protein family. RAD51 family members are highly similar to bacterial RecA and Saccharomyces cerevisiae Rad51, and are known to be involved in the homologous recombination and repair of DNA. This protein can interact with the ssDNA-binding protein RPA and RAD52, and it is thought to play roles in homologous pairing and strand transfer of DNA. RAD51 homolog protein isoform 2 is also found to interact with BRCA1 and BRCA2, which may be important for the cellular response to DNA damage. BRCA2 is shown to regulate both the intracellular localization and DNA-binding ability of this protein. Loss of these controls following BRCA2 inactivation may be a key event leading to genomic instability and tumorigenesis. Product

Pathways: DNA Reparatur