NOX3 Antikörper (C-Term)

Produktnummer ABIN966688

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NOX3 in IHC. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte und wurde in 3+ Publikationen erwähnt.

Kurzübersicht für NOX3 Antikörper (C-Term) (ABIN966688)

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NOX3 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-NOX3 Antikörper

Bindungsspezifität: C-Term

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human NOX3(NADPH oxidase 3)

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: 4 °C

Referenzen für anti-NOX3 Antikörper (ABIN966688)

Ueno, Takeya, Miyano, Kikuchi, Sumimoto: "The NADPH oxidase Nox3 constitutively produces superoxide in a p22phox-dependent manner: its regulation by oxidase organizers and activators." in: The Journal of biological chemistry, Vol. 280, Issue 24, pp. 23328-39, (2005) (PubMed).

Cheng, Ritsick, Lambeth: "Nox3 regulation by NOXO1, p47phox, and p67phox." in: The Journal of biological chemistry, Vol. 279, Issue 33, pp. 34250-5, (2004) (PubMed).

Cheng, Cao, Xu, van Meir, Lambeth: "Homologs of gp91phox: cloning and tissue expression of Nox3, Nox4, and Nox5." in: Gene, Vol. 269, Issue 1-2, pp. 131-40, (2001) (PubMed).

Details zu NOX3

Target: NOX3 (NADPH Oxidase 3 (NOX3))

Andere Bezeichnung: NOX3

Hintergrund: NADPH oxidase which constitutively produces superoxide upon formation of a complex with CYBA/p22phox. NOX3(NADPH oxidase 3) plays a role in the biogenesis of otoconia/otolith, which are crystalline structures of the inner ear involved in the perception of gravity. NOX3(NADPH oxidase 3) is activated by the ototoxic drug cisplatin and by NOXO1. NOX3 is cooperatively activated by NCF1 and NCF2 or NOXA1 in a phorbol 12-myristate 13-acetate (PMA)-dependent manner. It is inhibited by diphenyleneiodonium chloride and interacts with and stabilizes CYBA/p22phox. NOX3 is expressed in fetal kidney and to a lower extent in liver, lung and spleen.
Synonyms: MOX2