LKB1 Antikörper (C-Term)

Produktnummer ABIN966488

Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-LKB1 Antikörper wird verwendet zum Nachweis von LKB1 in Proben von Human. Er wurde validiert für WB und IHC (p).

Kurzübersicht für LKB1 Antikörper (C-Term) (ABIN966488)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser LKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-LKB1 Antikörper

Bindungsspezifität: C-Term

Kreuzreaktivität: Maus, Ratte (Rattus)

Kreuzreaktivität (Details): No cross reactivity with other proteins.

Produktmerkmale: Rabbit IgG polyclonal antibody for Serine/threonine-protein kinase STK11 (STK11) detection. Tested with WB, IHC-P in Human, Mouse, Rat.

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human STK11, different from the mouse sequence by one amino acid.< br/>Immunogen was affinity purified.

Isotyp: IgG

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Rekonstitution: Add 0.2 mL of distilled water will yield a concentration of 500 µg/mL.

Buffer: Each vial contains 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na2HPO4, 0.05 mg Thimerosal, 0.05 mg Sodium azide.

Konservierungsmittel: Sodium azide, Thimerosal (Merthiolate)

Handhabung: Avoid repeated freezing and thawing.

Lagerung: -20 °C

Informationen zur Lagerung: At -20 °C for one year. After reconstitution, at 4 °C for one month. It can also be aliquotted and stored frozen at -20 °C for a longer time.

Referenzen für anti-LKB1 Antikörper (ABIN966488)

Jenne, Reimann, Nezu, Friedel, Loff, Jeschke, Müller, Back, Zimmer: "Peutz-Jeghers syndrome is caused by mutations in a novel serine threonine kinase." in: Nature genetics, Vol. 18, Issue 1, pp. 38-43, (1998) (PubMed).

Details zu LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Andere Bezeichnung: Serine/threonine-protein kinase STK11

Hintergrund: Serine/threonine kinase 11 or LKB1 is a protein kinase which in humans is encoded by the STK11 gene. The STK11/LKB1 gene, which encodes a member of the serine/threonine kinase, regulates cell polarity and functions as a tumour suppressor Smith et al. (1999) found that the mouse Lkb1 gene encodes a protein showing strong sequence similarity to human LKB1. Karuman et al. (2001) demonstrated that LKB1 physically associates with p53 (191170) and regulates specific p53-dependent apoptosis pathways. Jenne et al. (1998) determined that the STK11 gene extends over 23 kb of genomic DNA and is composed of 9 exons, which are transcribed in telomere-to-centromere direction. Smith et al. (1999) found that the mouse Lkb1 gene consists of 10 exons covering approximately 15 kb.

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt