HTR2A Antikörper (C-Term)

Produktnummer ABIN966325

Dieser Polyklonal Antikörper detektiert spezifisch HTR2A in WB und IHC (p). Es zeigt Reaktivität gegenüber Proben von Human, Ratte und Maus. Es wurde in 2+ Publikationen zitiert.

Kurzübersicht für HTR2A Antikörper (C-Term) (ABIN966325)

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Reaktivität: Human, Ratte, Maus

Wirt: Bitte anfragen

Klonalität: Polyklonal

Konjugat: Dieser HTR2A Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-HTR2A Antikörper

Bindungsspezifität: AA 418-432, C-Term

Immunogen: A synthetic peptide corresponding to a sequence at the C-terminal of human HTR2A (418-432 aa), different from the mouse sequence by one amino acid.

Anwendungsinformationen

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Each vial contains 5mg BSA, 0.9mg NaCl, 0.2mg Na2HPO4

Konservierungsmittel: Thimerosal (Merthiolate), Sodium azide

Lagerung: -20 °C

Referenzen für anti-HTR2A Antikörper (ABIN966325)

Elphick, Querbes, Jordan, Gee, Eash, Manley, Dugan, Stanifer, Bhatnagar, Kroeze, Roth, Atwood: "The human polyomavirus, JCV, uses serotonin receptors to infect cells." in: Science (New York, N.Y.), Vol. 306, Issue 5700, pp. 1380-3, (2004) (PubMed).

Cook, Fletcher, Wainwright, Marks, Yan, Leventhal: "Primary structure of the human platelet serotonin 5-HT2A receptor: identify with frontal cortex serotonin 5-HT2A receptor." in: Journal of neurochemistry, Vol. 63, Issue 2, pp. 465-9, (1994) (PubMed).

Details zu HTR2A

Target: HTR2A (5-Hydroxytryptamine (serotonin) Receptor 2A (HTR2A))

Andere Bezeichnung: HTR2A

Hintergrund: The mammalian HTR2A 5-HT2A receptor is a subtype of the 5-HT2 receptor that belongs to the serotonin receptor family and is a G protein-coupled receptor (GPCR). This is the main excitatory receptor subtype among the GPCRs for serotonin (5-HT), although 5-HT2A may also have an inhibitory effect on certain areas such as the visual cortex and the orbit frontal cortex. This receptor was given importance first as the target of psychedelic drugs like LSD. Later it came back to prominence because it was also found to be mediating, at least partly, the action of many antipsychotic drugs, especially the atypical ones.5-HT2A also happens to be a necessary receptor for the spread of the human polyoma virus called JC virus. Sparkes et al. (1991) concluded that the gene is located on 13q14-q21 in man and on chromosome 14 in the mouse.

Pathways: JAK-STAT Signalweg, Inositol Metabolic Process, Regulation of Carbohydrate Metabolic Process