EGFR Antikörper

Produktnummer ABIN966041

Es sind 5+ Publikationen für dieses Produkt verfügbar. Der Kaninchen Polyklonal anti-EGFR Antikörper wird verwendet zum Nachweis von EGFR in Proben von Human, Maus und Ratte. Er wurde validiert für IHC.

Kurzübersicht für EGFR Antikörper (ABIN966041)

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser EGFR Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-EGFR Antikörper

Spezifität: EGFR (Ab-1092) antibody detects endogenous levels of total EGFR protein.

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: The antiserum was produced against synthesized non-phosphopeptide derived from human EGFR around the phosphorylation site of tyrosine 1092 (P-E-YP-I-N).

Anwendungsinformationen

Applikationshinweise: WB: 1:500~1:1000
IHC: 1:50~1:100.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100ug/100ul.

Buffer: Rabbit IgG in phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150mM NaCl, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-EGFR Antikörper (ABIN966041)

Mattila, Pellinen, Nevo, Vuoriluoto, Arjonen, Ivaska: "Negative regulation of EGFR signalling through integrin-alpha1beta1-mediated activation of protein tyrosine phosphatase TCPTP." in: Nature cell biology, Vol. 7, Issue 1, pp. 78-85, (2005) (PubMed).

Saito, Okada, Ohshima, Yamada, Sato, Uehara, Shimizu, Pessin, Mori: "Differential activation of epidermal growth factor (EGF) receptor downstream signaling pathways by betacellulin and EGF." in: Endocrinology, Vol. 145, Issue 9, pp. 4232-43, (2004) (PubMed).

Pao, Miller, Zakowski, Doherty, Politi, Sarkaria, Singh, Heelan, Rusch, Fulton, Mardis, Kupfer, Wilson, Kris, Varmus: "EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 101, Issue 36, pp. 13306-11, (2004) (PubMed).

Buerger, Nagel-Wolfrum, Kunz, Wittig, Butz, Hoppe-Seyler, Groner: "Sequence-specific peptide aptamers, interacting with the intracellular domain of the epidermal growth factor receptor, interfere with Stat3 activation and inhibit the growth of tumor cells." in: The Journal of biological chemistry, Vol. 278, Issue 39, pp. 37610-21, (2003) (PubMed).

Wang, Sun, Paller: "Ganglioside GM3 blocks the activation of epidermal growth factor receptor induced by integrin at specific tyrosine sites." in: The Journal of biological chemistry, Vol. 278, Issue 49, pp. 48770-8, (2003) (PubMed).

Details zu EGFR

Target: EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung: EGFR

Pathways: NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine