Es gibt 1 Publikation für dieses Produkt. Der Kaninchen Polyklonal anti-DCK Antikörper wird verwendet zum Nachweis von DCK in Proben von Human. Er wurde validiert für IHC.
This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung
-20 °C
Innoceta, Galluzzi, Ruzzo, Andreoni, Chiarantini, Magnani: "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells." in: Molecular and cellular biochemistry, Vol. 231, Issue 1-2, pp. 173-7, (2002) (PubMed).
Target
DCK
(Deoxycytidine Kinase (DCK))
Andere Bezeichnung
DCK
Hintergrund
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.