DCK Antikörper (N-Term)

Produktnummer ABIN965975

Der Kaninchen Polyklonal Anti-DCK Antikörper wurde für IHC validiert. Er ist geeignet, DCK in Proben von Human zu detektieren. Es ist 1 Publikation verfügbar.

Kurzübersicht für DCK Antikörper (N-Term) (ABIN965975)

Target: DCK (Deoxycytidine Kinase (DCK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser DCK Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-DCK Antikörper

Bindungsspezifität: N-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to N-terminal residues of human DCK (deoxycytidine kinase)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-DCK Antikörper (ABIN965975)

Innoceta, Galluzzi, Ruzzo, Andreoni, Chiarantini, Magnani: "Molecular basis of 2',3'-dideoxycytidine-induced drug resistance in human cells." in: Molecular and cellular biochemistry, Vol. 231, Issue 1-2, pp. 173-7, (2002) (PubMed).

Details zu DCK

Target: DCK (Deoxycytidine Kinase (DCK))

Andere Bezeichnung: DCK

Hintergrund: Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs. Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents. Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives. DCK is clinically important because of its relationship to drug resistance and sensitivity.