Cytokeratin 18 Antikörper (AA 391-483)

Produktnummer ABIN965957

Der Maus Monoklonal Anti-Cytokeratin 18-Antikörper wurde für WB, IHC und ELISA validiert. Er ist geeignet, Cytokeratin 18 in Proben von Human zu detektieren. Es sind 2+ Publikationen verfügbar.

Kurzübersicht für Cytokeratin 18 Antikörper (AA 391-483) (ABIN965957)

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Cytokeratin 18 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA

Klon: 4D11E4

Produktdetails anti-Cytokeratin 18 Antikörper

Bindungsspezifität: AA 391-483

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human Cytokeratin 18 (aa391-483) expressed in E. Coli.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunohistochemistry: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Referenzen für anti-Cytokeratin 18 Antikörper (ABIN965957)

Cheng, Liu, Ho, Chao, Pei, Hsu, Yeh, Ho, Tsai, Lai: "The influence of plectin deficiency on stability of cytokeratin18 in hepatocellular carcinoma." in: Journal of molecular histology, Vol. 39, Issue 2, pp. 209-16, (2008) (PubMed).

Walker, Harris, Holloway, McKenzie, Wells, Robinson, Morris: "Cytokeratin KRT8/18 expression differentiates distinct subtypes of grade 3 invasive ductal carcinoma of the breast." in: Cancer genetics and cytogenetics, Vol. 178, Issue 2, pp. 94-103, (2007) (PubMed).

Details zu Cytokeratin 18

Target: Cytokeratin 18 (KRT18) (Keratin 18 (KRT18))

Andere Bezeichnung: Cytokeratin 18

Hintergrund: Cytokeratin 18, also known as CK18, CYK18, KRT18. Entrez Protein NP_000215. It encodes the type I intermediate filament chain keratin 18. Keratin 18, together with its filament partner keratin 8, are perhaps the most commonly found members of the intermediate filament gene family. They are expressed in single layer epithelial tissues of the body. Mutations in this gene have been linked to cryptogenic cirrhosis. Two transcript variants encoding the same protein have been found for this gene.
Synonyms: CK18, CYK18, KRT18

Molekulargewicht: 48kDa

Gen-ID: 3875

Pathways: Apoptose, Caspase Kaskade in der Apoptose