MME Antikörper

Produktnummer ABIN965758

Dieses Monoklonal-Antikörper erkennt spezifisch MME in IHC und ELISA. Er zeigt eine Reaktivität gegenüber Human und wurde in 2+ Publikationen erwähnt.

Kurzübersicht für MME Antikörper (ABIN965758)

Target: MME (Membrane Metallo-Endopeptidase (MME))

Reaktivität: Human

Wirt: Bitte anfragen

Klonalität: Monoklonal

Konjugat: Dieser MME Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA

Produktdetails anti-MME Antikörper

Spezifität: Ni-NTA purified recombinant human CD-10 expressed in E. Coli strain BL21 (DE3).

Aufreinigung: Antibodies are purified by protein G affinity chromatography.

Isotyp: IgG2b

Anwendungsinformationen

Applikationshinweise: IHC(P): Dilution 1: 100- 1: 200
IHC(F): Dilution 1: 200- 1: 400
ELISA: Propose dilution 1: 10000.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Lagerung: -20 °C

Referenzen für anti-MME Antikörper (ABIN965758)

Sato, Itoh, Hinoda, Ohe, Nakagawa, Ueda, Yachi, Imai: "Expression of CD10/neutral endopeptidase in normal and malignant tissues of the human stomach and colon." in: Journal of gastroenterology, Vol. 31, Issue 1, pp. 12-7, (1996) (PubMed).

Inukai, Sugita, Iijima, Tezuka, Goi, Kojika, Shiraishi, Kagami, Nakazawa: "Expression of granulocyte colony-stimulating factor receptor on CD10-positive human B-cell precursors." in: British journal of haematology, Vol. 89, Issue 3, pp. 623-6, (1995) (PubMed).

Details zu MME

Target: MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung: CD10

Substanzklasse: Chemical

Hintergrund: CD10 is a 100kDa glycoprotein, also designated Common Acute Lymphocytic Leukemia Antigen (CALLA). It is a cell surface enzyme with neutral metalloendopeptidase activity which inactivates a variety of biologically active peptides. CD10 is expressed on the cells of lymphoblastic, Burkitt's, and follicular germinal center lymphomas, and on cells from patients with chronic myelocytic leukemia (CML). It is also expressed on the surface of normal early lymphoid progenitor cells, immature B cells within adult bone marrow and germinal center B cells within lymphoid tissue. CD10 is also present on breast myoepithelial cells, bile canaliculi, fibroblasts, with especially high expression on the brush border of kidney and gut epithelial cells.

Gen-ID: 4311

Pathways: RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration