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BTK Antikörper

BTK Reaktivität: Human WB, ELISA, IHC Monoclonal unconjugated
Produktnummer ABIN965707
  • Target Alle BTK Antikörper anzeigen
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Reaktivität
    • 151
    • 90
    • 79
    • 14
    • 6
    • 4
    • 2
    Human
    Wirt
    Bitte anfragen
    Klonalität
    • 145
    • 38
    Monoklonal
    Konjugat
    • 71
    • 15
    • 12
    • 9
    • 8
    • 8
    • 8
    • 8
    • 8
    • 7
    • 7
    • 5
    • 3
    • 3
    • 3
    • 3
    • 3
    • 2
    Dieser BTK Antikörper ist unkonjugiert
    Applikation
    • 109
    • 66
    • 40
    • 40
    • 36
    • 27
    • 18
    • 18
    • 11
    • 10
    • 9
    • 3
    • 2
    • 2
    • 2
    • 1
    Western Blotting (WB), ELISA, Immunohistochemistry (IHC)
    Spezifität
    Ni-NTA purified truncated recombinant BTK expressed in E. Coli strain BL21 (DE3)
    Aufreinigung
    Crude ascites.
    Isotyp
    IgG1
    Top Product
    Discover our top product BTK Primärantikörper
  • Applikationshinweise
    Western Blot: 1: 500- 1: 2,000
    IHC(P): 1: 500- 1: 2,000
    ELISA: Propose dilution 1: 10,000.
    Determining optimal working dilutions by titration test.
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Lagerung
    -20 °C
  • Tamagnone, Lahtinen, Mustonen, Virtaneva, Francis, Muscatelli, Alitalo, Smith, Larsson, Alitalo: "BMX, a novel nonreceptor tyrosine kinase gene of the BTK/ITK/TEC/TXK family located in chromosome Xp22.2." in: Oncogene, Vol. 9, Issue 12, pp. 3683-8, (1994) (PubMed).

    Yamada, Kawakami, Kimura, Fukamachi, Baier, Altman, Kato, Inagaki, Kawakami: "Structure and expression of novel protein-tyrosine kinases, Emb and Emt, in hematopoietic cells." in: Biochemical and biophysical research communications, Vol. 192, Issue 1, pp. 231-40, (1993) (PubMed).

    Thomas, Sideras, Smith, Vorechovský, Chapman, Paul: "Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes." in: Science (New York, N.Y.), Vol. 261, Issue 5119, pp. 355-8, (1993) (PubMed).

  • Target
    BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))
    Andere Bezeichnung
    BTK (BTK Produkte)
    Synonyme
    BTK antikoerper, atk antikoerper, bpk antikoerper, xla antikoerper, imd1 antikoerper, agmx1 antikoerper, psctk1 antikoerper, AGMX1 antikoerper, AT antikoerper, ATK antikoerper, BPK antikoerper, IMD1 antikoerper, PSCTK1 antikoerper, XLA antikoerper, AI528679 antikoerper, xid antikoerper, Bruton tyrosine kinase antikoerper, Bruton agammaglobulinemia tyrosine kinase antikoerper, BTK antikoerper, btk antikoerper, Btk antikoerper
    Hintergrund
    Brutons tyrosine kinase (BTK) is a member of the BTK/ Tec family of cytoplasmic tyrosine kinases.All members of the family contain SH3 and SH2 domains and, with the exception of Txk and Dsrc28C, also contain a pleckstrin homology (PH) and a Tec homology (TH) domain in their amino termini.BTK plays an important role in B cell development. Activation of B cells by various ligands is accompanied by BTK membrane translocation mediated by its PH domain binding to phosphatidylinositol-3,4,5trisphosphate. The membrane located BTK is active and associated with transient phosphorylation of two tyrosine residues, Tyr551 and Tyr223. Tyr551 in the activation loop is transphosphorylated by the Src family tyrosine kinase, leading to autophosphorylation at Tyr223 within the SH3 domain, which is necessary for full activation.
    Gen-ID
    695
    Pathways
    Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling
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