ABL2 Antikörper

Produktnummer ABIN965499

Dieses Anti-ABL2-Antikörper ist ein Maus Monoklonal-Antikörper zur Detektion von ABL2 in WB, ELISA und IF. Geeignet für Human und Maus.

Kurzübersicht für ABL2 Antikörper (ABIN965499)

Target: ABL2

Reaktivität: Human, Maus

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser ABL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunofluorescence (IF)

Klon: 1H1

Produktdetails anti-ABL2 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of ABL2 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Western Bloting: 1/500 - 1/2000.
Immunofluorescence: 1/200 - 1/1000.
ELISA: Propose dilution 1/10000.
Not yet tested in other applications.
Determining optimal working dilutions by titration test.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu ABL2

Target: ABL2

Andere Bezeichnung: ABL2

Hintergrund: ABL2 (ARG, Abl-related gene), together with c-Abl, forms the Abl family of mammalian non-receptor tyrosine kinases. ABL2 and c-Abl share 89%, 90 and 93% identity in their SH3, SH2 and tyrosine domain, but only 29% identity in the carboxy-terminal half. The human c-Abl and ABL2 genes are expressed ubiquitously. ABL2 had been detected predominantly in the cytoplasm, whereas c-Abl shows both cytoplasmic and nuclear localization. c-Abl is involved in two different chromosomal translocations present in human leukemias, which generate Bcr-Abl and TEL-Abl. Recently, TEL-ARG fusion transcripts have also been identified in acute myeloid leukemias (AML). The Abl family kinases may also interact with receptor tyrosine signaling pathways and regulate cellular function such as cell cycle progression, gene transcription and organization of the actin cytoskeletons in neurons.
Synonyms: ARG, ABLL, FLJ22224, FLJ31718, FLJ41441

Molekulargewicht: 128kDa

Gen-ID: 27