ABI1 Antikörper (C-Term)

Produktnummer ABIN965496

Dieses Anti-ABI1-Antikörper ist ein Kaninchen Polyklonal-Antikörper zur Detektion von ABI1 in IHC. Geeignet für Human und Maus. Dieses Primary Antibody wurde in 5+ Publikationen zitiert.

Kurzübersicht für ABI1 Antikörper (C-Term) (ABIN965496)

Target: ABI1 (Abl-Interactor 1 (ABI1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ABI1 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Produktdetails anti-ABI1 Antikörper

Bindungsspezifität: C-Term

Aufreinigung: Purified by antigen-specific affinity chromatography.

Immunogen: Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to C-terminal residues of human ABI1 (Abl-interactor 1)

Anwendungsinformationen

Applikationshinweise: ELISA, Western blotting: 1µg/ml for 2hrs.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: This antibody is stored in PBS, 50% glycerol

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Referenzen für anti-ABI1 Antikörper (ABIN965496)

Yamamoto, Suzuki, Sakaki: "Isolation of hNap1BP which interacts with human Nap1 (NCKAP1) whose expression is down-regulated in Alzheimer's disease." in: Gene, Vol. 271, Issue 2, pp. 159-69, (2001) (PubMed).

Fan, Goff: "Abl interactor 1 binds to sos and inhibits epidermal growth factor- and v-Abl-induced activation of extracellular signal-regulated kinases." in: Molecular and cellular biology, Vol. 20, Issue 20, pp. 7591-601, (2000) (PubMed).

Ziemnicka-Kotula, Xu, Gu, Potempska, Kim, Jenkins, Trenkner, Kotula: "Identification of a candidate human spectrin Src homology 3 domain-binding protein suggests a general mechanism of association of tyrosine kinases with the spectrin-based membrane skeleton." in: The Journal of biological chemistry, Vol. 273, Issue 22, pp. 13681-92, (1998) (PubMed).

Taki, Shibuya, Taniwaki, Hanada, Morishita, Bessho, Yanagisawa, Hayashi: "ABI-1, a human homolog to mouse Abl-interactor 1, fuses the MLL gene in acute myeloid leukemia with t(10;11)(p11.2;q23)." in: Blood, Vol. 92, Issue 4, pp. 1125-30, (1998) (PubMed).

Biesova, Piccoli, Wong: "Isolation and characterization of e3B1, an eps8 binding protein that regulates cell growth." in: Oncogene, Vol. 14, Issue 2, pp. 233-41, (1997) (PubMed).

Details zu ABI1

Target: ABI1 (Abl-Interactor 1 (ABI1))

Andere Bezeichnung: ABI1

Hintergrund: The ABI1 (Abl-interactor 1) may act in negative regulation of cell growth and transformation by interacting with nonreceptor tyrosine kinases ABL1 and/ or ABL2. The ABI1 may play a role in regulation of EGF-induced Erk pathway activation. It is involved in cytoskeletal reorganization and EGFR signaling. Together with EPS8 It participates in transduction of signals from Ras to Rac.

Pathways: RTK Signalweg, Response to Water Deprivation, ER-Nucleus Signaling