Cbl-Interacting Protein Sts-1 (STS1) (C-Term) Antikörper

Details zu Produkt Nr. ABIN964881, Anbieter: Anmelden zum Anzeigen
Antigen
  • STS-1
  • STS1
  • TULA-2
  • p70
  • 2810457I06Rik
  • BB125008
  • RGD1310357
  • Sts-1
  • ubiquitin associated and SH3 domain containing B
  • ubiquitin associated and SH3 domain containing, B
  • UBASH3B
  • Ubash3b
Epitop
C-Term
4
2
2
2
1
1
1
1
1
1
Reaktivität
Maus
28
14
14
2
2
2
2
2
1
1
Wirt
Kaninchen
21
4
4
Klonalität
Polyklonal
Applikation
ELISA, Western Blotting (WB)
27
19
11
6
3
2
2
2
2
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Immunogen This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the of mouse Sts-1.
Isotyp IgG
Produktmerkmale Concentration Definition: by UV absorbance at 280 nm
Sterilität Sterile filtered
Antigen
Andere Bezeichnung Sts-1 (STS1 Antibody Abstract)
Hintergrund Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.  Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.  Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.   Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
Synonyms: Cbl interacting protein p70 antibody, Cbl interacting protein Sts 1 antibody, Nm23 phosphorylated unknown substrate antibody, p70 antibody, SH3 domain containing 70 kDa protein antibody
Gen-ID 84959, 24497612
UniProt Q8TF42
Applikations-hinweise This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.63 mg/mL
Buffer 0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Bilder des Herstellers
Western Blotting (WB) image for anti-Cbl-Interacting Protein Sts-1 (STS1) (C-Term) antibody (ABIN964881) Western blot using Affinity Purified anti-Sts-1 antibody shows detection of a band ~...
Immunohistochemistry (IHC) image for anti-Cbl-Interacting Protein Sts-1 (STS1) (C-Term) antibody (ABIN964881) Immunohistochemistry with anti-Sts-1 antibody showing Sts-1 staining of histiocytic e...
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