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UBASH3B Antikörper (C-Term)

STS1 Reaktivität: Maus WB, ELISA Wirt: Kaninchen Polyclonal unconjugated
Produktnummer ABIN964881
  • Target Alle UBASH3B (STS1) Antikörper anzeigen
    UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))
    Bindungsspezifität
    • 3
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    C-Term
    Reaktivität
    • 17
    • 8
    • 8
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    Maus
    Wirt
    • 12
    • 3
    • 3
    Kaninchen
    Klonalität
    • 16
    • 2
    Polyklonal
    Konjugat
    • 18
    Dieser UBASH3B Antikörper ist unkonjugiert
    Applikation
    • 15
    • 8
    • 7
    • 6
    • 4
    • 3
    • 1
    • 1
    Western Blotting (WB), ELISA
    Produktmerkmale
    Concentration Definition: by UV absorbance at 280 nm
    Sterilität
    Sterile filtered
    Immunogen
    This affinity purified antibody was prepared from whole rabbit serum produced by repeated immunizations with a synthetic peptide corresponding to the of mouse Sts-1.
    Isotyp
    IgG
    Top Product
    Discover our top product STS1 Primärantikörper
  • Applikationshinweise
    This affinity purified antibody has been tested for use in ELISA and by western blot.  Specific conditions for reactivity should be optimized by the end user. Expect a band
    Beschränkungen
    Nur für Forschungszwecke einsetzbar
  • Format
    Liquid
    Konzentration
    0.63 mg/mL
    Buffer
    0.02 M Potassium Phosphate, 0.15 M Sodium Chloride, pH 7.2
    Konservierungsmittel
    Sodium azide
    Vorsichtsmaßnahmen
    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
    Lagerung
    -20 °C
  • Carpino, Turner, Mekala, Takahashi, Zang, Geiger, Doherty, Ihle: "Regulation of ZAP-70 activation and TCR signaling by two related proteins, Sts-1 and Sts-2." in: Immunity, Vol. 20, Issue 1, pp. 37-46, (2004) (PubMed).

    Carpino, Kobayashi, Zang, Takahashi, Jou, Feng, Nakajima, Ihle: "Identification, cDNA cloning, and targeted deletion of p70, a novel, ubiquitously expressed SH3 domain-containing protein." in: Molecular and cellular biology, Vol. 22, Issue 21, pp. 7491-500, (2002) (PubMed).

  • Target
    UBASH3B (STS1) (Cbl-Interacting Protein Sts-1 (STS1))
    Andere Bezeichnung
    Sts-1 (STS1 Produkte)
    Synonyme
    STS-1 antikoerper, STS1 antikoerper, TULA-2 antikoerper, p70 antikoerper, 2810457I06Rik antikoerper, BB125008 antikoerper, RGD1310357 antikoerper, Sts-1 antikoerper, ubiquitin associated and SH3 domain containing B antikoerper, ubiquitin associated and SH3 domain containing, B antikoerper, UBASH3B antikoerper, Ubash3b antikoerper
    Hintergrund
    Sts-1 is a protein that inhibits endocytosis of epidermal growth factor receptor (EGFR) and platelet-derived growth factor receptor.  Sts-1 and Sts-2 (formerly p70 and Clip4, respectively) have been found to interact with Cbl, an ubiquitin ligase that plays a critical role in attenuation of receptor tyrosine kinase signaling by inducing ubiquitination and promoting their sorting for endosomal degradation.  Sts-1 and Sts-2 contain SH3 domains that interact with Cbl, Ub-associated domains, which bind directly to mono-Ub or to the EGFR/Ub chimera, as well as phosphoglycerate mutase domains that mediate oligomerization of Sts-1/2.   Sts-1 and Sts-2 also have been found to negatively regulate signaling pathways that control T cell receptors, which in turn affect the extent and duration of the T cell response to foreign pathogens.
    Synonyms: Cbl interacting protein p70 antibody, Cbl interacting protein Sts 1 antibody, Nm23 phosphorylated unknown substrate antibody, p70 antibody, SH3 domain containing 70 kDa protein antibody
    Gen-ID
    84959, 24497612
    UniProt
    Q8TF42
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