XBP1 Antikörper (C-Term)

Produktnummer ABIN955595

Produktdetails anti-XBP1 Antikörper

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Bindungsspezifität: AA 224-252, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects XBP1 / TREB5 (C-term).

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse

Aufreinigung: Protein A column followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 224-252 amino acids from the C-terminal region of human XBP1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to six months or (in aliquots) at -20 °C for longer.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1 / TREB5 (XBP1 Produkte)

Synonyme: treb5 antikoerper, xXBP1 antikoerper, xbp2 antikoerper, XBP1P1 antikoerper, XBPP1 antikoerper, xbp1 antikoerper, TREB5 antikoerper, XBP-1 antikoerper, XBP2 antikoerper, D11Ertd39e antikoerper, TREB-5 antikoerper, HTF antikoerper, cb918 antikoerper, id:ibd1195 antikoerper, trebf antikoerper, wu:fb02h05 antikoerper, wu:fb63f10 antikoerper, xbp1a antikoerper, xbp1b antikoerper, X-box binding protein 1 antikoerper, X-box binding protein 1 L homeolog antikoerper, xbp1 antikoerper, XBP1 antikoerper, Xbp1 antikoerper, xbp1.L antikoerper

Hintergrund: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER), the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1). The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1(S), which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1(U), is constitutively expressed, and thought to function as a negative feedback regulator of XBP1(S), which shuts off transcription of target genes during the recovery phase of ER stress. A pseudogene of XBP1 has been identified and localized to chromosome 5.Synonyms: Tax-responsive element-binding protein 5, X-box-binding protein 1, XBP-1, XBP2

Gen-ID: 7494

NCBI Accession: NP_001073007

Pathways: ER-Nucleus Signaling, Unfolded Protein Response