RAD17 Antikörper (Middle Region)

Produktnummer ABIN954430

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch RAD17 in WB, FACS und EIA. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für RAD17 Antikörper (Middle Region) (ABIN954430)

Target: RAD17

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser RAD17 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Produktdetails anti-RAD17 Antikörper

Bindungsspezifität: AA 225-254, Middle Region

Spezifität: This antibody recognizes Human RAD17 (Center).

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 225-254 amino acids from the Central region of Human RAD17

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu RAD17

Target: RAD17

Andere Bezeichnung: RAD17

Hintergrund: The protein encoded by this gene is highly similar to the gene product of Schizosaccharomyces pombe rad17, a cell cycle checkpoint gene required for cell cycle arrest and DNA damage repair in response to DNA damage. This protein shares strong similarity with DNA replication factor C (RFC), and can form a complex with RFCs. This protein binds to chromatin prior to DNA damage and is phosphorylated by the checkpoint kinase ATR following damage. This protein recruits the RAD1-RAD9-HUS1 checkpoint protein complex onto chromatin after DNA damage, which may be required for its phosphorylation. The phosphorylation of this protein is required for the DNA-damage-induced cell cycle G2 arrest, and is thought to be a critical early event during checkpoint signaling in DNA-damaged cells. Eight alternatively spliced transcript variants of this gene, which encode four distinct proteins, have been reported. Two pseudogenes, located on chromosomes 7 and 13, have been identified.Synonyms: Cell cycle checkpoint protein RAD17, R24L, RF-C/activator 1 homolog

Molekulargewicht: 77055 Da

Gen-ID: 5884

NCBI Accession: NP_002864