MLH1 Antikörper (Middle Region)

Produktnummer ABIN953460

Der Kaninchen Polyklonal anti-MLH1 Antikörper (ABIN953460) detektiert spezifisch MLH1 in WB, FACS und EIA. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MLH1 Antikörper (Middle Region) (ABIN953460)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser MLH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Enzyme Immunoassay (EIA)

Produktdetails anti-MLH1 Antikörper

Bindungsspezifität: AA 459-488, Middle Region

Spezifität: This antibody recognizes MLH1.

Kreuzreaktivität (Details): Species reactivity (tested):Human

Aufreinigung: Purified through a Protein A column followed by peptide affinity purification

Immunogen: Synthetic peptide - KLH conjugated - corresponding to the central region (between 459-488aa) of human MLH1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS with 0.09 % (W/V) Sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Andere Bezeichnung: MLH1

Hintergrund: The MLH1 gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC). It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined.Synonyms: COCA2, DNA mismatch repair protein Mlh1

Gen-ID: 4292

NCBI Accession: NP_000240

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response