GREM1 Antikörper (C-Term)

Produktnummer ABIN952628

Der Kaninchen Polyklonal Anti-GREM1-Antikörper wurde für WB und EIA validiert. Er ist geeignet, GREM1 in Proben von Human zu detektieren.

Kurzübersicht für GREM1 Antikörper (C-Term) (ABIN952628)

Target: GREM1 (Gremlin 1 (GREM1))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-GREM1 Antikörper

Bindungsspezifität: AA 110-139, C-Term

Spezifität: This antibody recognizes Human Gremlin-1 / GREM1 (C-term).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 110-139 amino acids from the C-terminal region of Human Gremlin-1 / GREM1

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: Gremlin-1 / GREM1

Hintergrund: This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.Synonyms: CKTSF1B1, Cell proliferation-inducing gene 2 protein, Cysteine knot superfamily 1 BMP antagonist 1, DAN domain family member 2, DAND2, DRM, GREM-1, IHG-2, PIG2

Molekulargewicht: 20697 Da

Gen-ID: 26585

NCBI Accession: NP_001178252

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location