GREM1 Antikörper (C-Term)

Produktnummer ABIN5531272

Produktdetails anti-GREM1 Antikörper

Target: GREM1 (Gremlin 1 (GREM1))

Bindungsspezifität: AA 147-175, C-Term

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GREM1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Aufreinigung: This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis

Immunogen: This GREMLIN antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 147-175 amino acids from the C-terminal region of mouse GREMLIN.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: For WB starting dilution is: 1:1000

For IHC-P starting dilution is: 1:50~100

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 2 mg/mL

Buffer: Supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Store at 4°C for three months and -20°C, stable for up to one year. As with all antibodies care should be taken to avoid repeated freeze thaw cycles. Antibodies should not be exposed to prolonged high temperatures.

Details zu GREM1

Target: GREM1 (Gremlin 1 (GREM1))

Andere Bezeichnung: GREMLIN (GREM1 Produkte)

Synonyme: grem1 antikoerper, MGC136702 antikoerper, zgc:136702 antikoerper, GREM1 antikoerper, drm antikoerper, pig2 antikoerper, dand2 antikoerper, ihg-2 antikoerper, gremlin antikoerper, Cktsf1b1 antikoerper, Drm antikoerper, Grem antikoerper, ld antikoerper, gremlin-1 antikoerper, CKTSF1B1 antikoerper, DAND2 antikoerper, DRM antikoerper, GREMLIN antikoerper, IHG-2 antikoerper, cktsf1b1 antikoerper, gremlin 1a, DAN family BMP antagonist antikoerper, gremlin 1, DAN family BMP antagonist antikoerper, gremlin 1 antikoerper, gremlin 1, DAN family BMP antagonist L homeolog antikoerper, grem1a antikoerper, GREM1 antikoerper, LOC662541 antikoerper, grem1 antikoerper, Grem1 antikoerper, grem1.L antikoerper

Hintergrund: GREMLIN is a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth.

Molekulargewicht: 21 kDa

Gen-ID: 23892

UniProt: O70326

Pathways: Regulation of Muscle Cell Differentiation, Tube Formation, Maintenance of Protein Location