GLIS2 Antikörper (Middle Region)

Produktnummer ABIN952526

Der Kaninchen Polyklonal Anti-GLIS2-Antikörper wurde für WB und EIA validiert. Er ist geeignet, GLIS2 in Proben von Human zu detektieren.

Kurzübersicht für GLIS2 Antikörper (Middle Region) (ABIN952526)

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GLIS2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Produktdetails anti-GLIS2 Antikörper

Bindungsspezifität: AA 172-202, Middle Region

Spezifität: This antibody recognizes Human GLIS2 (Center).

Aufreinigung: Protein A column, followed by peptide affinity purification

Immunogen: KLH conjugated synthetic peptide between 172-202 amino acids from the Central region of Human GLIS2.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS containing 0.09 % (W/V) Sodium Azide as preservative

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu GLIS2

Target: GLIS2 (GLIS Family Zinc Finger 2 (GLIS2))

Andere Bezeichnung: GLIS2

Hintergrund: This gene is a member of the GLI-similar zinc finger protein family and encodes a nuclear transcription factor with five C2H2-type zinc finger domains. The protein encoded by this gene is widely expressed at low levels in the neural tube and peripheral nervous system and likely promotes neuronal differentiation. It is abundantly expressed in the kidney and may have a role in the regulation of kidney morphogenesis. p120 regulates the expression level of this protein and induces the cleavage of this protein's C-terminal zinc finger domain. This protein also promotes the nuclear translocation of p120. Mutations in this gene cause nephronophthisis (NPHP), an autosomal recessive kidney disease characterized by tubular basement membrane disruption, interstitial lymphohistiocytic cell infiltration, and development of cysts at the corticomedullary border of the kidneys.Synonyms: GLI-similar 2, NKL, Neuronal Krueppel-like protein, Zinc finger protein GLIS2

Molekulargewicht: 55689 Da

Gen-ID: 84662

NCBI Accession: NP_115964