CD247 Antikörper (AA 151-164) (FITC)

Produktnummer ABIN951240

Der Hamster Monoklonal Anti-CD247-Antikörper wurde für FACS und IF validiert. Er ist geeignet, CD247 in Proben von Human und Maus zu detektieren.

Kurzübersicht für CD247 Antikörper (AA 151-164) (FITC) (ABIN951240)

Target: CD247 (CD247 Molecule (CD247))

Reaktivität: Human, Maus

Wirt: Hamster

Klonalität: Monoklonal

Konjugat: Dieser CD247 Antikörper ist konjugiert mit FITC

Applikation: Flow Cytometry (FACS), Immunofluorescence (IF)

Klon: H146-968

Produktdetails anti-CD247 Antikörper (FITC)

Bindungsspezifität: AA 151-164

Spezifität: The antibody reacts with CD3 zeta chain (CD247), which is a component of TCR/CD3 complex expressed on T cells.

Kreuzreaktivität (Details): Species reactivity (tested):Human and Mouse.

Produktmerkmale: Synonyms: T3Z, TCRZ, CD3 zeta chain, T-cell surface glycoprotein CD3 zeta chain, T-cell receptor T3zeta chain

Immunogen: Synthetic peptide corresponding to amino acids 151-164 of Mouse CD3 zeta

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Flow Cytometry: 2 μg/mL (starting point).
Other applications not tested.
Optimal dilutions are dependent on conditions and should be determined by the user.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1.0 mg/mL

Buffer: Phosphate buffered saline (PBS), pH ~7.4 with 15 mM Sodium Azide as preservative.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C. DO NOT FREEZE! This product is photosensitive and should be protected from light.
Shelf life: one year from despatch.

Haltbarkeit: 12 months

Details zu CD247

Target: CD247 (CD247 Molecule (CD247))

Andere Bezeichnung: CD247 / CD3Z

Hintergrund: CD3 complex is crucial in transducing antigen-recognition signals into the cytopasm of T cells and in regulating the cell surface expression of the TCR complex. T cell activation through the antigen receptor (TCR) involves the cytoplasmic tails of the CD3 subunits CD3 gamma, CD3 delta, CD3 epsilon and CD3 zeta (CD247). These CD3 subunits are structurally related members of the immunoglobulins super family encoded by closely linked genes on human chromosome 11. The CD3 components have long cytoplasmic tails that associate with cytoplasmic signal transduction molecules. This association is mediated at least in part by a double tyrosine-based motif present in a single copy in the CD3 subunits. CD3 may play a role in TCR-induced growth arrest, cell survival and proliferation.Synonyms: CD3 zeta chain, T-cell receptor T3 zeta chain, T-cell surface glycoprotein CD3 zeta chain, T3Z, TCRZ

Gen-ID: 12503

UniProt: P24161

Pathways: T-Zell Rezeptor Signalweg, CXCR4-mediated Signaling Events, Ubiquitin Proteasome Pathway