CTNNB1 Antikörper (Catenin (Cadherin-Associated Protein), beta 1, 88kDa) (AA 653-681)

Details for Product anti-CTNNB1 Antibody No. ABIN951058
Antigen
Epitop
AA 653-681, C-Term
63
17
16
16
15
15
14
14
10
10
8
7
6
6
4
4
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Human
510
223
203
63
49
40
27
21
14
13
12
11
9
7
7
5
1
Wirt
Kaninchen
323
199
2
2
Klonalität
Polyklonal
Konjugat
Dieser CTNNB1 Antikörper ist unkonjugiert
15
9
9
6
6
6
4
4
3
3
3
3
3
3
Applikation
Enzyme Immunoassay (EIA), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
462
207
182
140
109
101
72
32
22
16
13
10
8
7
4
3
3
2
Optionen
Immunogen KLH conjugated synthetic peptide between 653-681 amino acids from the C-terminal region of Human Catenin beta-1. Genename: CTNNB1
Isotyp Ig Fraction
Spezifität This antibody recognizes Human Catenin beta-1 (C-term).
Reinigung Affinity Chromatography on Protein A
Antigen
Andere Bezeichnung Catenin beta-1 (CTNNB1 Antibody Abstract)
Hintergrund The protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.Synonyms: Beta-catenin, CTNNB, CTNNB1
Molekulargewicht 85497 Da
Gen-ID 1499
NCBI Accession NP_001091679
Pathways WNT Signalweg, Intracellular Steroid Hormone Receptor Signaling Pathway, Peptide Hormone Metabolism, Regulation of Muscle Cell Differentiation, Cell-Cell Junction Organization, Tube Formation, Maintenance of Protein Location, Signaling Events mediated by VEGFR1 and VEGFR2
Applikations-hinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS, 0.09 % Sodium Azide
Konservierungs-mittel Sodium azide
Vorsichtsmaßnahmen WARNING: Reagents contain sodium azide. Sodium azide is very toxic if ingested or inhaled. Avoid contact with skin, eyes, or clothing. Wear eye or face protection when handling. If skin or eye contact occurs, wash with copious amounts of water. If ingested or inhaled, contact a physician immediately. Sodium azide yields toxic hydrazoic acid under acidic conditions. Dilute azide-containing compounds in running water before discarding to avoid accumulation of potentially explosive deposits in lead or copper plumbing.
Handhabung Avoid repeated freezing and thawing.
Bilder des Herstellers
Image no. 1 for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 653-681), (C-Term) antibody (ABIN951058) Confocal immunofluorescent analysis of Catenin beta-1 Antibody (C-term) Cat.-No AP511...
Image no. 2 for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 653-681), (C-Term) antibody (ABIN951058) Formalin fixed, paraffin embedded human stomach tissuem stained with Catenin beta-1 A...
Image no. 3 for anti-Catenin (Cadherin-Associated Protein), beta 1, 88kDa (CTNNB1) (AA 653-681), (C-Term) antibody (ABIN951058) Western blot analysis of CTNB1 (arrow) using Catenin beta-1 Antibody (C-term) Cat.-No...
Produkt verwendet in: Chairoungdua, Smith, Pochard, Hull, Caplan: "Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling." in: The Journal of cell biology, Vol. 190, Issue 6, pp. 1079-91, 2010 (PubMed).

Guo, Shen, Liao, Lian, Wang: "NGX6 inhibits cell invasion and adhesion through suppression of Wnt/beta-catenin signal pathway in colon cancer." in: Acta biochimica et biophysica Sinica, Vol. 42, Issue 7, pp. 450-6, 2010 (PubMed).

Mirza, Sun, Zhao, Potula, Frey, Vogel, Malik, Zhao: "FoxM1 regulates re-annealing of endothelial adherens junctions through transcriptional control of beta-catenin expression." in: The Journal of experimental medicine, Vol. 207, Issue 8, pp. 1675-85, 2010 (PubMed).

Teng, Wang, Wang, Wang: "[Effect of siRNA-mediated beta-catenin gene on Wnt signal pathway in lung adenocarcinoma A549 cell]." in: Zhonghua yi xue za zhi, Vol. 90, Issue 14, pp. 988-92, 2010 (PubMed).

Zhou, Sandercock, Fraser, Ridlova, Stephens, Schenauer, Yokoi-Fong, Barsky, Leary, Hershey, Doudna, Robinson: "Mass spectrometry reveals modularity and a complete subunit interaction map of the eukaryotic translation factor eIF3." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 105, Issue 47, pp. 18139-44, 2008 (PubMed).