ASXL1 Antikörper (AA 521-549)

Produktnummer ABIN950543

Der Kaninchen Polyklonal Anti-ASXL1-Antikörper wurde für WB, FACS, IF, IHC (p) und EIA validiert. Er ist geeignet, ASXL1 in Proben von Human und Maus zu detektieren.

Kurzübersicht für ASXL1 Antikörper (AA 521-549) (ABIN950543)

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASXL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Enzyme Immunoassay (EIA)

Produktdetails anti-ASXL1 Antikörper

Bindungsspezifität: AA 521-549

Spezifität: This antibody detects ASXL1 at Center.

Kreuzreaktivität (Details): Species reactivity (tested):Mouse.

Aufreinigung: Affinity Chromatography on Protein A

Immunogen: KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.25 mg/mL

Buffer: PBS, 0.09 % Sodium Azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store the antibody undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Details zu ASXL1

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Andere Bezeichnung: ASXL1

Hintergrund: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.Synonyms: Additional sex combs-like protein 1, KIAA0978, Putative Polycomb group protein ASXL1

Molekulargewicht: 165432 Da

Gen-ID: 171023

NCBI Accession: NP_056153

Pathways: Retinoic Acid Receptor Signaling Pathway