ASXL1 Antikörper (AA 521-549)

Produktnummer ABIN655084

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch ASXL1 in WB, FACS, IF und IHC (p). Es zeigt Reaktivität gegenüber Proben von Maus.

Kurzübersicht für ASXL1 Antikörper (AA 521-549) (ABIN655084)

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Reaktivität: Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser ASXL1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunofluorescence (IF), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Klon: RB24070

Produktdetails anti-ASXL1 Antikörper

Bindungsspezifität: AA 521-549

Aufreinigung: This antibody is purified through a protein A column, followed by peptide affinity purification.

Immunogen: This ASXL1 antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 521-549 amino acids from the Central region of human ASXL1.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: IF: 1:10~50. WB: 1:1000. IHC-P: 1:50~100. FC: 1:10~50

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Purified polyclonal antibody supplied in PBS with 0.09 % (W/V) sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Maintain refrigerated at 2-8 °C for up to 6 months. For long term storage store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Haltbarkeit: 6 months

Details zu ASXL1

Target: ASXL1 (Additional Sex Combs Like 1 (ASXL1))

Andere Bezeichnung: ASXL1

Hintergrund: This gene is similar to the Drosophila additional sex combs gene, which encodes a chromatin-binding protein required for normal determination of segment identity in the developing embryo. The protein is a member of the Polycomb group of proteins, which are necessary for the maintenance of stable repression of homeotic and other loci. The protein is thought to disrupt chromatin in localized areas, enhancing transcription of certain genes while repressing the transcription of other genes. The protein encoded by this gene functions as a ligand-dependent co-activator for retinoic acid receptor in cooperation with nuclear receptor coactivator 1. Mutations in this gene are associated with myelodysplastic syndromes and chronic myelomonocytic leukemia. Alternative splicing results in multiple transcript variants.

Molekulargewicht: 165432

Gen-ID: 171023

NCBI Accession: NP_056153

UniProt: Q8IXJ9

Pathways: Retinoic Acid Receptor Signaling Pathway