Integrin Alpha2b Antikörper

Produktnummer ABIN94111

Dieses Maus Monoklonal-Antikörper erkennt spezifisch Integrin Alpha2b in FACS und IHC (fro). Er zeigt eine Reaktivität gegenüber Human und Non-Human Primate und wurde in 1 Publikation erwähnt.

Kurzübersicht für Integrin Alpha2b Antikörper (ABIN94111)

Target: Integrin Alpha2b (CD41)

Reaktivität: Human, Non-Human Primate

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Integrin Alpha2b Antikörper ist unkonjugiert

Applikation: Flow Cytometry (FACS), Immunohistochemistry (Frozen Sections) (IHC (fro))

Klon: HIP8

Produktdetails anti-Integrin Alpha2b Antikörper

Verwendungszweck: Anti-Hu CD41a Purified

Spezifität: The antibody HIP8 reacts with an extracellular epitope on alpha (a) subunit of CD41 (heavy chain, 120 kDa). CD41 is mainly expressed on platelets and megakaryocytes. The antibody HIP8 blocks platelet aggregation and completely inhibits ADP-, epinephrine-, and collagen-induced platelet activation, and partially inhibits ristocetin- and thrombin-induced platelet activation. HIP8 is useful in the morphological and physiological studies o platelets and megakaryocytes.

Kreuzreaktivität (Details): Human, Non-Human Primates

Aufreinigung: Purified by protein-A affinity chromatography.

Reinheit: > 95 % (by SDS-PAGE)

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: Recommended dilution: 1-4 μg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 1 mg/mL

Buffer: Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Do not freeze.

Lagerung: 4 °C

Informationen zur Lagerung: Store at 2-8°C. Do not freeze.

Referenzen für anti-Integrin Alpha2b Antikörper (ABIN94111)

Wu: "[Production and application of anti-human platelet GP IIb/IIIa monoclonal antibodies]." in: Zhonghua yi xue za zhi, Vol. 69, Issue 8, pp. 427-30, 30, (1990) (PubMed).

Details zu Integrin Alpha2b

Target: Integrin Alpha2b (CD41)

Hintergrund: Integrin subunit alpha 2b,CD41 (platelet glycoprotein IIb) is composed of two subunits (120 kDa a, alpha and 23 kDa b, beta) that interact with CD61 in the presence of calcium to form a functional adhesive protein receptor. Upon blood vessel damage, this receptor binds to a variety of proteins including von Willebrand factor, fibrinogen, fibronectin and vitronectin. CD41 is mainly expressed on megakaryocyte-platelet lineage, but generally belongs to the antigens that are expressed during early stages of hematopoietic differentiation.,GT, GTA, GP2B, HPA3, GPIIb

Gen-ID: 3674

UniProt: P08514

Pathways: Integrin Complex