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MME Antikörper

Name: MME Antikörper
Brand: antibodies-online
SKU: ABIN93930
Price: 300.56 EUR
Availability: InStock

MME Reaktivität: Human FACS, IP Wirt: Maus Monoclonal MEM-78 unconjugated

Flow cytometry surface staining pattern of human peripheral whole blood stained using anti-human CD10 (MEM-78) purified antibody (concentration in sample 1 μg/mL, GAM APC).

FACS

Surface staining of NALM-6 human pre-B cell leukemia cell line with anti-human CD10 (MEM-78) PE.

FACS

Separation of human neutrophil granulocytes (red-filled) from CD10 negative lymphocytes (black-dashed) in flow cytometry analysis (surface staining) of human peripheral whole blood stained using anti-human CD10 (MEM-78) purified antibody (concentration in sample 1 μg/mL, GAM APC).

FACS

3 Abbildungen

(1 reference)

Produktnummer ABIN93930

Datenblatt (PDF)

Target Alle MME Antikörper anzeigen

MME (Membrane Metallo-Endopeptidase (MME))
Reaktivität
213

58

50

3

2

2

2

2

2

1

1

1

1
Human
Wirt
111

108

2
Maus
Passende Sekundärantikörper
Klonalität
115

105

2
Monoklonal
Konjugat
108

19

19

14

9

6

5

3

2

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1

1
Dieser MME Antikörper ist unkonjugiert
Applikation
133

100

80

69

38

28

22

21

13

13

10

8

6

5

5

3

2

2

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP)

Spezifität

The antibody MEM-78 reacts with an extracellular epitope CD10 antigen (CALLA - Common acute lymphatic leukemia antigen), a 100 kDa type II integral membrane protein.

Kreuzreaktivität (Details)

Human

Aufreinigung

Purified by protein-A affinity chromatography.

Reinheit

> 95 % (by SDS-PAGE)

Immunogen

NALM-6 human pre-B cell line

Klon

MEM-78

Isotyp

IgG1

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Applikationshinweise

Flow cytometry: Recommended dilution: 1 μg/mL.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Do not freeze.
Angelisová, Drbal, Horejsí, Cerný: "Association of CD10/neutral endopeptidase 24.11 with membrane microdomains rich in glycosylphosphatidylinositol-anchored proteins and Lyn kinase." in: Blood, Vol. 93, Issue 4, pp. 1437-9, (1999) (PubMed).
Target

MME (Membrane Metallo-Endopeptidase (MME))

Andere Bezeichnung

CD10 (MME Produkte)

Synonyme

CALLA antikoerper, CD10 antikoerper, NEP antikoerper, SFE antikoerper, 6030454K05Rik antikoerper, C85356 antikoerper, Nep antikoerper, neprilysin antikoerper, membrane metalloendopeptidase antikoerper, membrane metallo endopeptidase antikoerper, membrane metallo-endopeptidase antikoerper, MME antikoerper, Mme antikoerper

Substanzklasse

Chemical

Hintergrund

Membrane metalloendopeptidase,CD10 (neutral endopeptidase –, NEP, common acute lymphocytic leukemia antigen –, CALLA, membrane metallo-endopeptidase –, MME, enkefalinase) is a 100- kDa cell surface zinc metalloprotease, cleaving peptide bonds on the N-terminus of hydrophobic amino acids and inactivating multiple physiologically active peptids. CD10 is expressed on various normal cell types, including lymphoid precursor cells, germinal center B lymhocytes, and some epithelial cells, and its expression level serves as a marker for diagnostics of many carcinomas. CD10 is also a differentiation antigen for early B-lymphoid progenitors in the B-cell differentiation pathway and has a key role in regulation of growth, differentiation and signal transduction of many cellular systems.,CALLA, Neprilysin, Neutral endopeptidase, Enkephalinase, Atriopeptidase, MME

Gen-ID

4311

UniProt

P08473

Pathways

RTK Signalweg, Peptide Hormone Metabolism, Regulation of Systemic Arterial Blood Pressure by Hormones, Smooth Muscle Cell Migration