Insulin Receptor Antikörper (Middle Region)

Produktnummer ABIN926933

Der Kaninchen Polyklonal Anti-Insulin Receptor-Antikörper wurde für WB und IHC validiert. Er ist geeignet, Insulin Receptor in Proben von Human, Maus, Ratte, Hund, Kaninchen, Zebrafisch (Danio rerio) und Xenopus laevis zu detektieren.

Kurzübersicht für Insulin Receptor Antikörper (Middle Region) (ABIN926933)

Target: Insulin Receptor (INSR)

Reaktivität: Human, Maus, Ratte, Hund, Kaninchen, Zebrafisch (Danio rerio), Xenopus laevis

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Insulin Receptor Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-Insulin Receptor Antikörper

Bindungsspezifität: Middle Region

Kreuzreaktivität: Maus, Ratte (Rattus), Hund, Kaninchen, Zebrafisch (Brachydanio rerio), Frosch

Aufreinigung: Purified

Immunogen: INSR antibody was raised in rabbit using the middle region of INSR as the immunogen

Anwendungsinformationen

Applikationshinweise: WB: 0.2-1 µg/mL
Optimal conditions should be determined by the investigator.

Kommentare:

INSR Blocking Peptide, (ABIN5614204), is also available for use as a blocking control in assays to test for specificity of this INSR antibody

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Lyophilized

Konzentration: Lot specific

Buffer: Lyophilized powder. Add 50 µL of distilled water. Final antibody concentration is 1 mg/mL in PBS buffer.

Handhabung: Avoid repeated freeze/thaw cycles.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 4 °C, following reconstitution, aliquot and store at -20 °C.

Details zu Insulin Receptor

Target: Insulin Receptor (INSR)

Andere Bezeichnung: INSR

Hintergrund: This receptor binds insulin and has a tyrosine-protein kinase activity. Isoform Short has a higher affinity for insulin. INSR mediates the metabolic functions of insulin. INSR binding to insulin stimulates association of the receptor with downstream mediators including IRS1 and phosphatidylinositol 3'-kinase (PI3K). INSR can activate PI3K either directly by binding to the p85 regulatory subunit, or indirectly via IRS1. When present in a hybrid receptor with IGF1R, it binds IGF1. Synonyms: Polyclonal INSR antibody, Anti-INSR antibody, insulin receptor antibody, CD220 antibody, HHF5 antibody.

Pathways: NF-kappaB Signalweg, RTK Signalweg, AMPK Signaling, Carbohydrate Homeostasis, Regulation of Cell Size, Regulation of Carbohydrate Metabolic Process, Growth Factor Binding, Negative Regulation of Transporter Activity