TLR3 Antikörper

Produktnummer ABIN920707

Dieses Maus Monoklonal-Antikörper erkennt spezifisch TLR3 in WB und FACS. Er zeigt eine Reaktivität gegenüber Human.

Kurzübersicht für TLR3 Antikörper (ABIN920707)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TLR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS)

Produktdetails anti-TLR3 Antikörper

Spezifität: Reacts with TLR3.

Sterilität: 0.2 μm filtered

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Flow cytometry: (intracellular) Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mL of 0.2 µm sterile filtered antibody solution at 100 µg/mL in PBS containing 0.1% protein stabilizer.

Lagerung: 4 °C

Details zu TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Andere Bezeichnung: TLR3

Hintergrund: Toll-like receptors (TLR) are highly conserved throughout evolution and have been implicated in the innate defence to many pathogens. In Drosophila toll is required for the anti-fungal response, while the related 18-wheeler is involved in antibacterial defences. In mammals, TLR identified as type I transmembrane signalling receptors with pattern recognition capabilies, have been implicated in the innate host defence to pathogens. As investigated so far all functional characterized TLR signal via the TLR/IL-1 receptor (IL-1R) pathway where recruitment of MyD88 seems to be essential. Viral replication within infected cells results in generation of dsRNA which can stimulate immune cells. Recent data show that TLR3 acts as a receptor involved in the recognition of dsRNA, indicating a role for TLR3 in viral recognition and innate defence.

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades