PVRL2 Antikörper

Produktnummer ABIN920706

Der Ratte Monoklonal anti-PVRL2 Antikörper (Klon 502-57) (ABIN920706) detektiert spezifisch PVRL2 in WB, FACS, IHC und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human und Maus.

Kurzübersicht für PVRL2 Antikörper (ABIN920706)

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Reaktivität: Human, Maus

Wirt: Ratte

Klonalität: Monoklonal

Konjugat: Dieser PVRL2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Flow Cytometry (FACS), Immunohistochemistry (IHC), Immunoprecipitation (IP)

Klon: 502-57

Produktdetails anti-PVRL2 Antikörper

Spezifität: Reacts with nectin-2.

Aufreinigung: Purified

Immunogen: The extracellular domain of mouse nectin-2.

Isotyp: IgG2a

Anwendungsinformationen

Applikationshinweise: Immunohistochemistry: (frozen sections) Use at a 1:10 dilution. Flow cytometry: Use at a 1:10 dilution. Western blot: Use at a 1:10 dilution. Fixation with PFA or acetone/methanol is recommended.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: 1 mL of 100 µg/mL

Lagerung: 4 °C

Details zu PVRL2

Target: PVRL2 (Poliovirus Receptor-Related 2 (Herpesvirus Entry Mediator B) (PVRL2))

Andere Bezeichnung: Nectin-2

Hintergrund: Nectin (originally isolated as poliovirus receptor- related protein (PRR)) is a cell-cell adhesion molecule of the immunoglobulin supergene family. Nectin is co-localized with afadin at cadherin-based cell-cell adherence juctions in various tissues and cell lines. The nectin family consists of nectin-1, nectin-2 and nectin-3. Nectin-2 is a plasma membrane adhesion molecule localized at adherens junctions which is widely expressed in various cells lines including neuronal, endothelial, epithelial and hematopoietic cells. Next to its role in adherens junctions it functions as alphaherpus virus receptor and acts also as intercellular adhesion molecule and pseudorabies virus receptor. Disruption of mouse nectin-2 leads to infertility of male mice. Synonyms: PRR2, CD112

Pathways: Regulation of Leukocyte Mediated Immunity, Positive Regulation of Immune Effector Process, Cell-Cell Junction Organization