TLR3 Antikörper (N-Term)

Produktnummer ABIN920638

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch TLR3 in WB und IHC. Er zeigt eine Reaktivität gegenüber Human und Maus.

Kurzübersicht für TLR3 Antikörper (N-Term) (ABIN920638)

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Reaktivität: Human, Maus

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser TLR3 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC)

Produktdetails anti-TLR3 Antikörper

Bindungsspezifität: N-Term

Produktmerkmale: Positive Control: Located in the membrane and expressed at high levels in placenta and pancreas. Also detected in CD11c+ immature dendritic cells. Only expressed in dendritic cells and not in other leukocytes, including monocyte precursors.

Aufreinigung: Antigen Immunoaffinity purified

Immunogen: Rabbit polyclonal TLR3 antibody was raised against a peptide corresponding to 15 amino acids near the amino terminus of TLR3.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Western blot: use at 1-2 µg/mL

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: Phosphate buffered saline with 0.02% sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Details zu TLR3

Target: TLR3 (Toll-Like Receptor 3 (TLR3))

Hintergrund: Toll-like receptors (TRLs) are evolutionarily conserved pattern-recognition molecules resembling the toll proteins that mediate antimicrobial responses in Drosophila. These proteins recognize different microbial products during infection and serve as an important link between the innate and adaptive immune responses. The TLRs act through adaptor molecules such as MyD88 and TIRAP to activate various kinases and transcription factors so the organism can respond to potential infection. TLR3 is known to recognize viral double-stranded RNA, as a molecular pattern associated with viral infection. Recently it has been shown to recognize viruses such as influenza A and West Nile Virus and can mediate entry of at least West Nile virus. Synonyms:

Molekulargewicht: 103.8 kDa

Pathways: TLR Signalweg, Activation of Innate immune Response, Hepatitis C, Toll-Like Receptors Cascades