APC Antikörper (AA 2751-2843) (AbBy Fluor® 350)

Produktnummer ABIN882922

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch APC in IF (cc) und IF (p). Er zeigt eine Reaktivität gegenüber Ratte.

Kurzübersicht für APC Antikörper (AA 2751-2843) (AbBy Fluor® 350) (ABIN882922)

Target: APC (Adenomatous Polyposis Coli (APC))

Reaktivität: Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser APC Antikörper ist konjugiert mit AbBy Fluor® 350

Applikation: Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p))

Produktdetails anti-APC Antikörper (AbBy Fluor® 350)

Bindungsspezifität: AA 2751-2843

Kreuzreaktivität: Ratte

Homologie: Human,Mouse,Cow,Pig,Horse,Rabbit

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human APC

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: Aqueous buffered solution containing 0.01M TBS ( pH 7.4) with 1 % BSA, 0.03 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Haltbarkeit: 12 months

Details zu APC

Target: APC (Adenomatous Polyposis Coli (APC))

Andere Bezeichnung: Adenomatous Polyposis Coli

Hintergrund:

Synonyms: GS, DP2, DP3, BTPS2, DP2.5, PPP1R46, Adenomatous polyposis coli protein, Protein APC, Deleted in polyposis 2.5, APC

Background: Tumor suppressor. Promotes rapid degradation of CTNNB1 and participates in Wnt signaling as a negative regulator. APC activity is correlated with its phosphorylation state. Activates the GEF activity of SPATA13 and ARHGEF4. Plays a role in hepatocyte growth factor (HGF)-induced cell migration. Required for MMP9 up-regulation via the JNK signaling pathway in colorectal tumor cells. Acts as a mediator of ERBB2-dependent stabilization of microtubules at the cell cortex. It is required for the localization of MACF1 to the cell membrane and this localization of MACF1 is critical for its function in microtubule stabilization.

Gen-ID: 324

UniProt: P25054

Pathways: WNT Signalweg, Stem Cell Maintenance, Cell-Cell Junction Organization