NLRP4 Antikörper (AA 351-450)

Produktnummer ABIN872353

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch NLRP4 in ELISA, IF (cc), IF (p), IHC (fro) und IHC (p). Er zeigt eine Reaktivität gegenüber Human und Ratte.

Kurzübersicht für NLRP4 Antikörper (AA 351-450) (ABIN872353)

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Reaktivität: Human, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP4 Antikörper ist unkonjugiert

Applikation: ELISA, Immunofluorescence (Cultured Cells) (IF (cc)), Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Frozen Sections) (IHC (fro)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p))

Produktdetails anti-NLRP4 Antikörper

Bindungsspezifität: AA 351-450

Spezifität: This antibody will detect multiple forms of NALP4, including the A, C and E Mouse variants.

Kreuzreaktivität: Human, Ratte

Homologie: Mouse,Pig,Horse

Aufreinigung: Purified by Protein A.

Immunogen: KLH conjugated synthetic peptide derived from human NALP4

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: ELISA 1:500-1000
IHC-P 1:200-400
IHC-F 1:100-500
IF(IHC-P) 1:50-200
IF(IHC-F) 1:50-200
IF(ICC) 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 μg/μL

Buffer: 0.01M TBS( pH 7.4) with 1 % BSA, 0.02 % Proclin300 and 50 % Glycerol.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Haltbarkeit: 12 months

Details zu NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Andere Bezeichnung: NALP4

Hintergrund:

Synonyms: NACHT, LRR and PYD domains-containing protein 4, Cancer/testis antigen 58, CT58, PAAD and NACHT-containing protein 2, PAN2, PYRIN and NACHT-containing protein 2, PYRIN-containing APAF1-like protein 4, PYPAF4, Ribonuclease inhibitor 2, NLRP4, NALP4, RNH2

Background: May be involved in inflammation and recognition of cytosolic pathogen-associated molecular patterns (PAMPs) not intercepted by membrane-bound receptors. Acts as a negative regulator of the type I interferon signaling pathway by serving as an adapter to promote DTX4-mediated ubiquitination of activated TBK1, and its subsequent degradation. Suppresses NF-kappaB induction by the cytokines TNFA and IL1B, suggesting that it operates at a point of convergence in these two cytokine signaling pathways.

Gen-ID: 147945

UniProt: Q96MN2

Pathways: Inflammasome