NLRP4 Antikörper (AA 121-149)

Produktnummer ABIN3032022

Der Kaninchen Polyklonal anti-NLRP4 Antikörper (ABIN3032022) detektiert spezifisch NLRP4 in ELISA und WB. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für NLRP4 Antikörper (AA 121-149) (ABIN3032022)

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser NLRP4 Antikörper ist unkonjugiert

Applikation: ELISA, Western Blotting (WB)

Produktdetails anti-NLRP4 Antikörper

Bindungsspezifität: AA 121-149

Verwendungszweck: NLRP4 Antibody

Aufreinigung: Antigen affinity

Immunogen: A portion of amino acids 121-149 from the human protein was used as the immunogen for this NLRP4 antibody.

Isotyp: Ig Fraction

Anwendungsinformationen

Applikationshinweise: Titration of the NLRP4 antibody may be required due to differences in protocols and secondary/substrate sensitivity.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: In 1X PBS, pH 7.4, with 0.09 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Aliquot the NLRP4 antibody and store frozen at -20oC or colder. Avoid repeated freeze-thaw cycles.

Details zu NLRP4

Target: NLRP4 (NLR Family, Pyrin Domain Containing 4 (NLRP4))

Andere Bezeichnung: NLRP4

Hintergrund: NALPs are cytoplasmic proteins that form a subfamily within the larger CATERPILLER protein family. Most short NALPs, such as NALP4, have an N-terminal pyrin (MEFV, MIM 608107) domain (PYD), followed by a NACHT domain, a NACHT-associated domain (NAD), and a C-terminal leucine-rich repeat (LRR) region. The long NALP, NALP1 (MIM 606636), also has a C-terminal extension containing a function to find domain (FIIND) and a caspase recruitment domain (CARD). NALPs are implicated in the activation of proinflammatory caspases (e.g., CASP1, MIM 147678) via their involvement in multiprotein complexes called inflammasomes (Tschopp et al., 2003 [PubMed 12563287]).

UniProt: Q96MN2

Pathways: Inflammasome