CHEK2 Antikörper (AA 514-518)
Kurzübersicht für CHEK2 Antikörper (AA 514-518) (ABIN871442)
Target
Alle CHEK2 Antikörper anzeigenReaktivität
Wirt
Klonalität
Konjugat
Applikation
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Bindungsspezifität
- AA 514-518
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Spezifität
- The antibody detects endogenous levels of total Chk2 protein.
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Aufreinigung
- Affinity purified
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Immunogen
- Peptide sequence around AA 514-518 (Q-P-S-T-S) derived from Chk2 Antibodies were produced by immunizing rabbits with synthetic peptide and KLH conjugates.
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anti-Checkpoint Kinase 2 (CHEK2) (pThr387) antibody
CHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, ELISA, IF, IHC (p) Wirt: Maus Monoclonal 4B7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 1-543) antibodyCHEK2 Reaktivität: Human WB, IP Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr383) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pSer516) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (pThr68) antibodyCHEK2 Reaktivität: Human, Maus, Ratte WB, ELISA, IHC, IF, ICC Wirt: Kaninchen Polyclonal unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Affe, Hund WB, IHC, IF, IHC (p), FACS Wirt: Maus Monoclonal 10G7 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IF, IHC (p), IP, FACS Wirt: Maus Monoclonal 5C4 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) antibodyCHEK2 Reaktivität: Human, Hund WB, IHC, IHC (p), IP, FACS Wirt: Maus Monoclonal 2H5 unconjugated
anti-Checkpoint Kinase 2 (CHEK2) (AA 111-141), (N-Term) antibodyCHEK2 Reaktivität: Human WB, IF, IHC (p), FACS Wirt: Kaninchen Polyclonal RB19067 unconjugated
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Applikationshinweise
- Western blotting: 1:500-1:1000
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Beschränkungen
- Nur für Forschungszwecke einsetzbar
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Format
- Liquid
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Konzentration
- 1 mg/mL
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Buffer
- Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol.
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Konservierungsmittel
- Sodium azide
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Vorsichtsmaßnahmen
- This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
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Lagerung
- 4 °C/-20 °C
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Informationen zur Lagerung
- Store at -20 °C for long term preservation (recommended). Store at 4 °C for short term use.
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- CHEK2 (Checkpoint Kinase 2 (CHEK2))
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Andere Bezeichnung
- Chk2
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Hintergrund
- The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Plays a central role in DNA repair by facilitating cellular response to DNA repair. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Involved in transcriptional regulation of P21 in response to DNA damage. Required for FANCD2 targeting to sites of DNA damage. May function as a transcriptional regulator. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation
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Molekulargewicht
- 62 kDa
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Gen-ID
- 11200
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NCBI Accession
- NP_001005
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UniProt
- O96017
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Pathways
- p53 Signalweg, Apoptose, Zellzyklus
Target
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