LKB1 Antikörper

Produktnummer ABIN865492

Dieser Maus Monoklonal Antikörper detektiert spezifisch LKB1 in WB, ELISA und FACS. Es zeigt Reaktivität gegenüber Proben von Human, Maus und Affe.

Kurzübersicht für LKB1 Antikörper (ABIN865492)

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Reaktivität: Human, Maus, Affe

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser LKB1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Flow Cytometry (FACS)

Klon: 4H12

Produktdetails anti-LKB1 Antikörper

Aufreinigung: Ascitic fluid

Immunogen: Purified recombinant fragment of human STK11 expressed in E. Coli.

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: WB: 1/500 - 1/2000, FC: 1/200-1/400, ELISA: Propose dilution 1/10000.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 100g/100l

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Details zu LKB1

Target: LKB1 (STK11) (serine/threonine Kinase 11 (STK11))

Andere Bezeichnung: STK11

Hintergrund: Essential role in G1 cell cycle arrest. Phosphorylates and activates members of the AMPK-related subfamily of protein kinases. Tumor suppressor.serine/threonine kinase 11,with two alternatively spliced isoforms,expressed in all tissues,strongly homolog of Xenopus early embryonic kinase 1 (XEEK1),tumor suppressor gene in hamartomas syndrome and in left sided colon carcinogenesis,mutated in sporadic testicular cancer,malignant melanomas and laryngeal tumors,playing a minor role in the development of ovarian carcinoma.LKB1 is a potential target for atherosclerosis and cancer and is shown to be mutated in patients with Peutz-Jeghers cancer syndrome. Tissue specificity: Ubiquitously expressed. Strongest expression in testis and fetal liver. Synonyms: PJS, LKB1, STK11

Molekulargewicht: 54kDa

Gen-ID: 6794

Pathways: AMPK Signaling, Carbohydrate Homeostasis, Regulation of Carbohydrate Metabolic Process, Warburg Effekt