TRF1 Antikörper

Produktnummer ABIN790393

Produktdetails anti-TRF1 Antikörper

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser TRF1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Immunohistochemistry (Frozen Sections) (IHC (fro))

Marke: IHC-plus™

Spezifität: Recognizes TTAGGG repeat binding factor 1 (TRF1) a ubiquitously expressed 60kD protein. Along with tankyrase-1, TIN2, and PINX1, TRF1 binds the double-stranded TTAGGG repeat of telomeres and regulates telomere length. Protection of telomeres-1 (POT1) is a single-stranded telomeric DNA-binding protein which controls the elongation of telomeres by telomerase. TRF1 mediates the loading of POT1 onto single stranded DNA, conveying information about telomere length to the telomere terminus, where telomerase is regulated. If the telomere is long enough, telomerase is inhibited. Additionally in conjunction with POT1 and TTAGGG repeat binding factor 1 (TRF2), TRF1 recruits factors to the telomere, inducing the formation of the protective t-loop. TRF1 along with TRF2, POT1, TIN2, TPP1, and Rap1 form the shelterin complex which distinguishes telomeres from sites of DNA damage. Reported to work in Western blotting applications.

Aufreinigung: Affinity purified

Immunogen: Recombinant TRF1

Type of Immunogen: Recombinant protein

Klon: BED5

Isotyp: IgG1

Anwendungsinformationen

Applikationshinweise: Approved: ELISA, IHC, IHC-Fr, IHC-P (10 μg/mL)

Usage: Immunohistochemistry: This product requires antigen retrieval using heat treatment prior to staining of paraffin sections. Sodium citrate buffer  pH 6.0 is recommended for this purpose Histology Positive Control Tissue: Human tonsil.

Kommentare:

Target Species of Antibody: Human

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: Lot specific

Buffer: PBS containing 0.09 % sodium azide. Sourced in TCS.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: avoid freeze thaw cycles.

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: Short term 4°C, long term aliquot and store at -20°C, avoid freeze-thaw cycles.

Details zu TRF1

Target: TRF1 (TERF1) (Telomeric Repeat Binding Factor (NIMA-Interacting) 1 (TERF1))

Andere Bezeichnung: TRF1 / TERF1 (TERF1 Produkte)

Synonyme: PIN2 antikoerper, TRBF1 antikoerper, TRF antikoerper, TRF1 antikoerper, hTRF1-AS antikoerper, t-TRF1 antikoerper, wu:fb74c04 antikoerper, TERF1 antikoerper, DKFZp459A0713 antikoerper, Pin2 antikoerper, Trbf1 antikoerper, Trf1 antikoerper, terf1 antikoerper, trf1 antikoerper, telomeric repeat binding factor 1 antikoerper, telomeric repeat binding factor (NIMA-interacting) 1 antikoerper, telomeric repeat binding factor (NIMA-interacting) 1 L homeolog antikoerper, TERF1 antikoerper, Terf1 antikoerper, terf1 antikoerper, Trf1 antikoerper, terf1.L antikoerper

Hintergrund: Name/Gene ID: TERF1

Synonyms: TERF1, HTRF1-AS, NIMA-interacting protein 2, PIN2, Telomeric protein Pin2/TRF1, TRBF1, TTAGGG repeat-binding factor 1, T-TRF1, TRF, TRF1

Gen-ID: 7013

Pathways: Zellzyklus, Telomere Maintenance, Hormone Transport, Chromatin Binding, Regulation of Cell Size, Positive Regulation of Endopeptidase Activity