KPNA1 Antikörper (N-Term)

Produktnummer ABIN783729

Produktdetails anti-KPNA1 Antikörper

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Bindungsspezifität: N-Term

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Enzyme Immunoassay (EIA)

Spezifität: This antibody detects KPNA1 / Importin alpha-1 at N-term.

Kreuzreaktivität (Details): Species reactivity (tested):Human, mouse, rat

Aufreinigung: Affinity chromatography purified via peptide column

Immunogen: 15 amino acid peptide near the amino terminus of human KPNA1

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Buffer: PBS containing 0.02 % sodium azide

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid repeated freezing and thawing.

Lagerung: 4 °C/-20 °C

Informationen zur Lagerung: Store at 2 - 8 °C for up to three months or (in aliquots) at -20 °C for longer.

Details zu KPNA1

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Andere Bezeichnung: KPNA1 / Importin alpha-1 (KPNA1 Produkte)

Synonyme: IPOA5 antikoerper, NPI-1 antikoerper, RCH2 antikoerper, SRP1 antikoerper, AW494490 antikoerper, NPI1 antikoerper, Rch2 antikoerper, mSRP1 antikoerper, si:ch211-161h7.7 antikoerper, karyopherin subunit alpha 1 antikoerper, importin alpha-1 subunit antikoerper, karyopherin (importin) alpha 1 antikoerper, karyopherin alpha 1 (importin alpha 5) antikoerper, KPNA1 antikoerper, Kpna1 antikoerper, EHI_124900 antikoerper, kpna1 antikoerper

Hintergrund: Karyopherin, a cytosolic and heterodimeric protein complex consisting of alpha and beta subunits, is responsible for targeting proteins with nuclear localization signals to the nuclear pore complex by an energy requiring, Ran-dependent mechanism. The alpha subunit and imported substrate enter the nucleus and accumulate in the nucleoplasm, while the beta subunit accumulates at the NPC. KPNA1, also known as importin alpha 5, is the alpha subunit of karyopherin, which forms a complex with importin subunit beta-1 and functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. It is ubiquitously expressed and polyubiquitinated in the presence of RAG1. KPNA1 interacts with various virus nucleoproteins, including those of Ebola and influenza.Synonyms: IPOA5, Karyopherin alpha 1, NPI-1, Nucleoprotein interactor 1, RAG cohort protein 2, RCH2, SRP1, SRP1-beta

Gen-ID: 3836

NCBI Accession: NP_002255

UniProt: P52294

Pathways: M Phase, Protein targeting to Nucleus