KPNA1 Antikörper (AA 8-538)

Produktnummer ABIN7156126

Produktdetails anti-KPNA1 Antikörper

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Bindungsspezifität: AA 8-538

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser KPNA1 Antikörper ist unkonjugiert

Applikation: ELISA, Immunohistochemistry (IHC)

Kreuzreaktivität: Human

Aufreinigung: >95%, Protein G purified

Immunogen: Recombinant Human Importin subunit alpha-5 protein (8-538AA)

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: Recommended dilution: IHC:1:20-1:200,

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Preservative: 0.03 % Proclin 300
Constituents: 50 % Glycerol, 0.01M PBS, PH 7.4

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.

Details zu KPNA1

Target: KPNA1 (Karyopherin alpha 1 (Importin alpha 5) (KPNA1))

Andere Bezeichnung: KPNA1 (KPNA1 Produkte)

Synonyme: IPOA5 antikoerper, NPI-1 antikoerper, RCH2 antikoerper, SRP1 antikoerper, AW494490 antikoerper, NPI1 antikoerper, Rch2 antikoerper, mSRP1 antikoerper, si:ch211-161h7.7 antikoerper, karyopherin subunit alpha 1 antikoerper, importin alpha-1 subunit antikoerper, karyopherin (importin) alpha 1 antikoerper, karyopherin alpha 1 (importin alpha 5) antikoerper, KPNA1 antikoerper, Kpna1 antikoerper, EHI_124900 antikoerper, kpna1 antikoerper

Hintergrund:

Background: Functions in nuclear protein import as an adapter protein for nuclear receptor KPNB1. Binds specifically and directly to substrates containing either a simple or bipartite NLS motif. Docking of the importin/substrate complex to the nuclear pore complex (NPC) is mediated by KPNB1 through binding to nucleoporin FxFG repeats and the complex is subsequently translocated through the pore by an energy requiring, Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta and the three components separate and importin-alpha and -beta are re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases Ran from importin. The directionality of nuclear import is thought to be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of Ran between the cytoplasm and nucleus. In vitro, mediates the nuclear import of human cytomegalovirus UL84 by recognizing a non-classical NLS.

Aliases: IMA5_HUMAN antibody, Importin alpha 1 subunit antibody, Importin alpha 5 antibody, Importin alpha S1 antibody, Importin subunit alpha-5, N-terminally processed antibody, IPO A5 antibody, IPOA 5 antibody, IPOA5 antibody, Karyopherin alpha 1 antibody, Karyopherin alpha 1 subunit antibody, Karyopherin subunit alpha-1 antibody, KPNA 1 antibody, KPNA1 antibody, mSRP 1 antibody, mSRP1 antibody, NPI 1 antibody, NPI-1 antibody, NPI1 antibody, Nucleoprotein interactor 1 antibody, RAG cohort protein 2 antibody, RCH 2 antibody, RCH2 antibody, Recombination activating gene cohort 2 antibody, SRP 1 antibody, SRP1 beta antibody, SRP1-beta antibody

UniProt: P52294

Pathways: M Phase, Protein targeting to Nucleus