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LIN28A Antikörper (N-Term)

Dieses Kaninchen Polyklonal-Antikörper erkennt spezifisch LIN28A in WB. Er zeigt eine Reaktivität gegenüber Human, Maus und Ratte.
Produktnummer ABIN783322

Kurzübersicht für LIN28A Antikörper (N-Term) (ABIN783322)

Target

Alle LIN28A Antikörper anzeigen
LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

Reaktivität

  • 99
  • 31
  • 28
  • 2
  • 2
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
Human, Maus, Ratte

Wirt

  • 84
  • 19
Kaninchen

Klonalität

  • 78
  • 25
Polyklonal

Konjugat

  • 53
  • 7
  • 6
  • 4
  • 3
  • 3
  • 3
  • 3
  • 3
  • 3
  • 2
  • 2
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
  • 1
Dieser LIN28A Antikörper ist unkonjugiert

Applikation

  • 67
  • 39
  • 26
  • 23
  • 19
  • 14
  • 13
  • 13
  • 11
  • 10
  • 9
  • 3
  • 3
  • 1
  • 1
Western Blotting (WB)
  • Bindungsspezifität

    • 15
    • 9
    • 9
    • 7
    • 7
    • 4
    • 3
    • 3
    • 2
    • 2
    • 2
    • 2
    • 2
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    • 1
    AA 1-5, N-Term

    Sequenz

    M-G-S-V-S

    Spezifität

    This antibody detects endogenous levels of total Lin28 protein.

    Kreuzreaktivität (Details)

    Species reactivity (tested):Human, Mouse, Rat

    Aufreinigung

    Affinity-chromatography using epitope-specific peptide

    Immunogen

    Peptide sequence around aa. 1~5 derived from Human Lin28
  • Applikationshinweise

    Optimal working dilution should be determined by the investigator.

    Beschränkungen

    Nur für Forschungszwecke einsetzbar
  • Format

    Liquid

    Konzentration

    1.0 mg/mL

    Buffer

    Phosphate buffered saline (without Mg2+ and Ca2+), pH 7.4, 150 mM NaCl, 0.02 % sodium azide and 50 % glycerol

    Konservierungsmittel

    Sodium azide

    Vorsichtsmaßnahmen

    This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

    Handhabung

    Avoid repeated freezing and thawing.

    Lagerung

    -20 °C

    Informationen zur Lagerung

    Store (in aliquots) at -20 °C.
  • Target

    LIN28A (Lin-28 Homolog A (C. Elegans) (LIN28A))

    Andere Bezeichnung

    LIN28

    Hintergrund

    Acts as a 'translational enhancer', driving specific mRNAs to polysomes and thus increasing the efficiency of protein synthesis. Its association with the translational machinery and target mRNAs results in an increased number of initiation events per molecule of mRNA and, indirectly, in stabilizing the mRNAs. Binds IGF2 mRNA, MYOD1 mRNA, ARBP/36B4 ribosomal protein mRNA and its own mRNA. Essential for skeletal muscle differentiation program through the translational up-regulation of IGF2 expression. Acts as a suppressor of microRNA (miRNA) biogenesis by specifically binding the precursor let-7 (pre-let-7), a miRNA precursor. Acts by binding pre-let-7 and recruiting ZCCHC11/TUT4 uridylyltransferase, leading to the terminal uridylation of pre-let-7. Uridylated pre-let-7 miRNAs fail to be processed by Dicer and undergo degradation. Degradation of pre-let-7 in embryonic stem (ES) cells contributes to the maintenance of ES cells.Synonyms: CSDD1, LIN-28, LIN28A, Lin-28 homolog A, ZCCHC1

    Molekulargewicht

    26 kDa

    Gen-ID

    79727

    NCBI Accession

    NP_078950

    UniProt

    Q9H9Z2

    Pathways

    Stem Cell Maintenance
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