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EGFR Antikörper

Name: EGFR Antikörper
Brand: antibodies-online
SKU: ABIN780370
Price: 409.87 EUR
Availability: InStock

EGFR Reaktivität: Human, Pferd FACS, IP, ICC, IHC (fro) Wirt: Maus Monoclonal EGFR1 unconjugated

Flow cytometry surface staining pattern of A-431 cells stained using anti-EGFR (EGFR1) purified antibody (concentration in sample 1 μg/mL) GAM APC. (EGFR Antikörper)

FACS

Separation of A-431 cells (red-filled) from SP2 cells (black-dashed) in flow cytometry analysis (surface staining) of cell lines stained using anti-EGFR (EGFR1) purified antibody (concentration in sample 1 μg/mL) GAM APC. (EGFR Antikörper)

FACS

2 Abbildungen

(3 Referenzen)

Produktnummer ABIN780370

Datenblatt (PDF)

Target Alle EGFR Antikörper anzeigen

EGFR (Epidermal Growth Factor Receptor (EGFR))
Reaktivität
759

299

287

25

25

24

20

14

7

3

2

2

1

1

1

1

1

1
Human, Pferd
Wirt
581

177

14

13

5

2

1

1
Maus
Passende Sekundärantikörper
Klonalität
543

246

2
Monoklonal
Konjugat
413

58

29

22

20

18

18

17

16

16

16

12

10

10

10

10

10

10

10

10

10

8

8

5

4

4

4

4

4

2

1

1

1

1

1

1
Dieser EGFR Antikörper ist unkonjugiert
Applikation
538

250

151

151

128

102

98

93

82

45

37

34

33

19

11

8

6

4

4

3

3

3

3

3

3

2

2

2

2

2

1

1

1

1

1

1

1

1

1

1

1

1
Flow Cytometry (FACS), Immunoprecipitation (IP), Immunocytochemistry (ICC), Immunohistochemistry (Frozen Sections) (IHC (fro))

Spezifität

The mouse monoclonal antibody EGFR1 reacts with extracellular domain of human protein kinase EGFR (ErbB1 / HER1), epitope within amino acids 6-273.

Keine Kreuzreaktivität

Maus, Ratte

Kreuzreaktivität (Details)

Human, Equine (Horse)

Aufreinigung

Purified by protein-A affinity chromatography.

Reinheit

> 95 % (by SDS-PAGE)

Immunogen

Human epidermoid carcinoma line A431

Klon

EGFR1

Isotyp

IgG2b kappa

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Applikationshinweise

Flow cytometry: Recommended dilution: 2-6 μg/mL.

Beschränkungen

Nur für Forschungszwecke einsetzbar
Konzentration

1 mg/mL

Buffer

Phosphate buffered saline (PBS), pH 7.4, 15 mM sodium azide

Konservierungsmittel

Sodium azide

Vorsichtsmaßnahmen

This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung

Do not freeze.

Lagerung

4 °C

Informationen zur Lagerung

Store at 2-8°C. Do not freeze.
Rebetz, Tian, Persson, Widegren, Salford, Englund, Gisselsson, Fan: "Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma." in: PLoS ONE, Vol. 3, Issue 4, pp. e1936, (2008) (PubMed).

Aigner, Juhl, Malerczyk, Tkybusch, Benz, Czubayko: "Expression of a truncated 100 kDa HER2 splice variant acts as an endogenous inhibitor of tumour cell proliferation." in: Oncogene, Vol. 20, Issue 17, pp. 2101-11, (2001) (PubMed).

Akiyama, Smith, Shimizu: "Changing patterns of localization of putative stem cells in developing human hair follicles." in: The Journal of investigative dermatology, Vol. 114, Issue 2, pp. 321-7, (2000) (PubMed).
Target

EGFR (Epidermal Growth Factor Receptor (EGFR))

Andere Bezeichnung

EGFR (EGFR Produkte)

Hintergrund

Epidermal growth factor receptor,The oncoprotein EGFR (epidermal growth factor receptor), also known as HER1 / ErbB1, is a member of ErbB family of cell surface receptor tyrosine kinases. This 170 kDa transmembrane glycoprotein is often associated with cancerogenesis, although its activation state is controlled at various levels including trafficking and degradation steps. Binding of receptor-specific ligands to the EGFR ectodomain results in formation of homodimeric or heterodimeric kinase-active complexes into which HER2 / ErbB2 is recruited as a preferred partner. Subsequent signaling cascades such as RAS/MAPK and PI3K/AKT pathways lead to cell proliferation and survival responses.,EGF-R, Her1, ERBB1, PIG61, NISBD2

Gen-ID

1956

UniProt

P00533

Pathways

NF-kappaB Signalweg, RTK Signalweg, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Stem Cell Maintenance, Hepatitis C, Positive Regulation of Response to DNA Damage Stimulus, Interaction of EGFR with phospholipase C-gamma, Thromboxane A2 Receptor Signaling, EGFR Downregulation, S100 Proteine