XBP1 Antikörper

Produktnummer ABIN8125764

Der Kaninchen Monoklonal anti-XBP1 Antikörper wird verwendet zum Nachweis von XBP1 in Proben von Human, Maus und Ratte. Er wurde validiert für WB, ELISA, IHC, IF und IP.

Kurzübersicht für XBP1 Antikörper (ABIN8125764)

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser XBP1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: AB1852

Produktdetails anti-XBP1 Antikörper

Verwendungszweck: XBP1 Rabbit mAb

Spezifität: This antibody detects endogenous levels of XBP1 protein.

Aufreinigung: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB, 1:1000-1:5000 | IHC, 1:200-1:1000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu XBP1

Target: XBP1 (X-Box Binding Protein 1 (XBP1))

Andere Bezeichnung: XBP1

Hintergrund:

Synonyms: XBP1, TREB5, XBP2, X-box-binding protein 1, XBP-1, Tax-responsive element-binding protein 5

Background: This gene encodes a transcription factor that regulates MHC class II genes by binding to a promoter element referred to as an X box. This gene product is a bZIP protein, which was also identified as a cellular transcription factor that binds to an enhancer in the promoter of the T cell leukemia virus type 1 promoter. It may increase expression of viral proteins by acting as the DNA binding partner of a viral transactivator. It has been found that upon accumulation of unfolded proteins in the endoplasmic reticulum (ER) , the mRNA of this gene is processed to an active form by an unconventional splicing mechanism that is mediated by the endonuclease inositol-requiring enzyme 1 (IRE1) . The resulting loss of 26 nt from the spliced mRNA causes a frame-shift and an isoform XBP1 (S) , which is the functionally active transcription factor. The isoform encoded by the unspliced mRNA, XBP1 (U) , is constitutively e

Gene Name: >>Protein processing in endoplasmic reticulum, >>Non-alcoholic fatty liver disease, >>Alzheimer disease, >>Parkinson disease, >>Amyotrophic lateral sclerosis, >>Spinocerebellar ataxia, >>Pathways of neurodegeneration-multiple diseases, >>Lipid and atherosclerosis

Protein Name: XBP1

Gen-ID: 7494

UniProt: P17861

Pathways: ER-Nucleus Signaling, Unfolded Protein Response