MLH1 Antikörper (AA 400-500)

Produktnummer ABIN8123089

Der Maus Monoklonal anti-MLH1 Antikörper (Klon AB1558) (ABIN8123089) detektiert spezifisch MLH1 in WB, IHC, ELISA und IF. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MLH1 Antikörper (AA 400-500) (ABIN8123089)

Target: MLH1 (MutL Homolog 1 (MLH1))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MLH1 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Klon: AB1558

Produktdetails anti-MLH1 Antikörper

Bindungsspezifität: AA 400-500

Verwendungszweck: MutL Protein Homolog 1 (MLH1) mouse mAb

Spezifität: This antibody detects endogenous levels of MLH1 protein.

Aufreinigung: The antibody was purified by protein G affinity chromatography.

Immunogen: A synthetic peptide corresponding to the amino acid region 400 - 500 of the human MutL Protein Homolog 1 protein.

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC, 1:100-1:500 | WB, 1:500-1:2000 | IF, 1:100-1:500 | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu MLH1

Target: MLH1 (MutL Homolog 1 (MLH1))

Andere Bezeichnung: MutL Protein Homolog 1

Hintergrund:

Synonyms: DNA mismatch repair protein Mlh1, MutL protein homolog 1, MLH1

Background: This gene was identified as a locus frequently mutated in hereditary nonpolyposis colon cancer (HNPCC) . It is a human homolog of the E. coli DNA mismatch repair gene mutL, consistent with the characteristic alterations in microsatellite sequences (RER+phenotype) found in HNPCC. Alternative splicing results in multiple transcript variants encoding distinct isoforms. Additional transcript variants have been described, but their full-length natures have not been determined. [provided by RefSeq, Nov 2009],

Gene Name: MLH1 COCA2

Protein Name: MutL Protein Homolog 1

Gen-ID: 4292

UniProt: P40692

Pathways: DNA Reparatur, Production of Molecular Mediator of Immune Response