FASL Antikörper (AA 121-170)

Produktnummer ABIN8121390

Der Kaninchen Polyklonal anti-FASL Antikörper wird verwendet zum Nachweis von FASL in Proben von Human, Maus und Ratte. Er wurde validiert für IHC, ELISA und IF.

Kurzübersicht für FASL Antikörper (AA 121-170) (ABIN8121390)

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser FASL Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC), ELISA, Immunofluorescence (IF)

Produktdetails anti-FASL Antikörper

Bindungsspezifität: AA 121-170

Verwendungszweck: FAS-L Antibody

Spezifität: The antibody detects endogenous FAS-L

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthetic peptide from human protein at AA range: 121-170

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: IHC 1:50-200, ELISA 1:10000-20000. IF 1:50-200

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu FASL

Target: FASL (Fas Ligand (TNF Superfamily, Member 6) (FASL))

Andere Bezeichnung: FAS-L

Hintergrund:

Synonyms: Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand, APTL, CD95 ligand, CD95-L, Fas antigen ligand, Fas ligand, FasL, CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane form, Tumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain, Soluble Fas ligand, sFasL), ADAM10-processed FasL form (APL), FasL intracellular domain (FasL ICD, SPPL2A-processed FasL form, SPA)]

Background: This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described. [provided by RefSeq, Nov 2014],

Gene Name: FASLG APT1LG1 CD95L FASL TNFSF6

Protein Name: Tumor necrosis factor ligand superfamily member 6 (Apoptosis antigen ligand) (APTL) (CD95 ligand) (CD95-L) (Fas antigen ligand) (Fas ligand) (FasL) (CD antigen CD178) [Cleaved into: Tumor necrosis factor ligand superfamily member 6, membrane formTumor necrosis factor ligand superfamily member 6, soluble form (Receptor-binding FasL ectodomain) (Soluble Fas ligand) (sFasL)ADAM10-processed FasL form (APL)FasL intracellular domain (FasL ICD) (SPPL2A-processed FasL form) (SPA)]

Gen-ID: 356

UniProt: P48023

Pathways: Apoptose, EGFR Signaling Pathway, Production of Molecular Mediator of Immune Response, Positive Regulation of Endopeptidase Activity