CYFIP2 Antikörper (AA 1171-1220)

Produktnummer ABIN8120893

Der Kaninchen Polyklonal anti-CYFIP2 Antikörper (ABIN8120893) detektiert spezifisch CYFIP2 in WB und ELISA. Dieser Antikörper reagiert spezifisch mit Proben aus Human, Maus und Ratte.

Kurzübersicht für CYFIP2 Antikörper (AA 1171-1220) (ABIN8120893)

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Reaktivität: Human, Maus, Ratte

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser CYFIP2 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA

Produktdetails anti-CYFIP2 Antikörper

Bindungsspezifität: AA 1171-1220

Verwendungszweck: CYFIP2 Antibody

Spezifität: CYFIP2 Polyclonal Antibody detects endogenous levels of CYFIP2

Aufreinigung: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.

Immunogen: Synthesized peptide derived from CYFIP2 at AA range: 1171-1220

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB 1:500-2000, ELISA 1:10000-20000

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: Liquid in PBS containing 50 % glycerol, 0.5 % BSA and 0.02 % sodium azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: -20 °C

Informationen zur Lagerung: Store at -20°C/1 year

Haltbarkeit: 12 months

Details zu CYFIP2

Target: CYFIP2 (Cytoplasmic FMR1 Interacting Protein 2 (CYFIP2))

Andere Bezeichnung: CYFIP2

Hintergrund:

Synonyms: Cytoplasmic FMR1-interacting protein 2 (p53-inducible protein 121)

Background: disease:Up-regulated significantly in CD4+ T lymphocytes from patients with multiple sclerosis (at protein level).,function:Involved in T-cell adhesion and p53-dependent induction of apoptosis. Does not bind RNA.,induction:By p53.,RNA editing:Partially edited. Editing appears to be brain-specific.,similarity:Belongs to the CYFIP family.,subcellular location:Highly expressed in the perinuclear region. Enriched in synaptosomes. Treatment with leptomycin-B triggers translocation to the nucleus.,subunit:Interacts with FMR1, FXR1 AND FXR2. Component of the WAVE1 complex composed of ABI2, CYFIP2, C3orf10/HSPC300, NCKAP1 and WASF1/WAVE1. CYFIP2 binds to activated RAC1 which causes the complex to dissociate, releasing activated WASF1. The complex can also be activated by NCK1.,

Gene Name: CYFIP2

Protein Name: CYFIP2

Gen-ID: 26999

UniProt: Q96F07

Pathways: RTK Signalweg, Apoptose, Positive Regulation of Endopeptidase Activity