BTK Antikörper

Produktnummer ABIN8120047

Der Kaninchen Monoklonal anti-BTK Antikörper (Klon AB2138) (ABIN8120047) detektiert spezifisch BTK in WB, ELISA, IHC, IF und IP. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für BTK Antikörper (ABIN8120047)

Target: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Monoklonal

Konjugat: Dieser BTK Antikörper ist unkonjugiert

Applikation: Western Blotting (WB), ELISA, Immunohistochemistry (IHC), Immunofluorescence (IF), Immunoprecipitation (IP)

Klon: AB2138

Produktdetails anti-BTK Antikörper

Verwendungszweck: BTK Rabbit mAb

Spezifität: This antibody detects endogenous levels of BTK protein.

Aufreinigung: The antibody was purified by protein A affinity chromatography.

Immunogen: Recombinant protein (or fragment).

Isotyp: IgG

Anwendungsinformationen

Applikationshinweise: WB, 1:2000-1:10000 | IHC, 1:1000-1:4000 | IF, 1:200-1:1000 | IP, 0. 5 μg-4 μg antibody for 200 μg-400 μg extracts of whole cells. | ELISA, Recommended starting concentration is 1 μg/mL. Please optimize the concentration based on your specific assay requirements.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Buffer: The antibody is provided in liquid form in phosphate - buffered saline with 50 % glycerol, 0.05 % BSA, and 0.05 % Proclin 300.

Konservierungsmittel: ProClin

Vorsichtsmaßnahmen: This product contains ProClin: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: Avoid freeze / thaw cycles

Lagerung: -20 °C

Informationen zur Lagerung: Store at-20°C. Avoid freeze / thaw cycles.

Details zu BTK

Target: BTK (Bruton Agammaglobulinemia tyrosine Kinase (BTK))

Andere Bezeichnung: BTK

Hintergrund:

Synonyms: BTK, AGMX1, ATK, BPK, Tyrosine-protein kinase BTK, Agammaglobulinaemia tyrosine kinase, ATK, B-cell progenitor kinase, BPK, Bruton tyrosine kinase

Background: The protein encoded by this gene plays a crucial role in B-cell development. Mutations in this gene cause X-linked agammaglobulinemia type 1, which is an immunodeficiency characterized by the failure to produce mature B lymphocytes, and associated with a failure of Ig heavy chain rearrangement. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Dec 2013],

Gene Name: BTK

Protein Name: BTK

Gen-ID: 695

UniProt: Q06187

Pathways: Fc-epsilon Rezeptor Signalübertragung, Hormone Transport, Activation of Innate immune Response, Regulation of Leukocyte Mediated Immunity, Production of Molecular Mediator of Immune Response, Toll-Like Receptors Cascades, BCR Signaling