Thyroperoxidase Antikörper (C-Term)

Produktnummer ABIN8114021

Der Kaninchen Polyklonal anti-Thyroperoxidase Antikörper wird verwendet zum Nachweis von Thyroperoxidase in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für Thyroperoxidase Antikörper (C-Term) (ABIN8114021)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser Thyroperoxidase Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-Thyroperoxidase Antikörper

Bindungsspezifität: C-Term

Verwendungszweck: TPO Antibody - C-terminal region

Sequenz: VQDQLMNEEL TERLFVLSNS STLDLASINL QRGRDHGLPG YNEWREFCGL

Homologie: Cow: 92%, Dog: 100%, Guinea Pig: 100%, Horse: 93%, Human: 100%, Mouse: 100%, Rat: 100%

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the C terminal region of human TPO

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP44312-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Andere Bezeichnung: TPO

Hintergrund:

Background Information: This gene encodes a membrane-bound glycoprotein. The encoded protein acts as an enzyme and plays a central role in thyroid gland function. The protein functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA. Multiple transcript variants encoding distinct isoforms have been identified for this gene, but the full-length nature of some variants has not been determined.

Gene Name: thyroid peroxidase

Alternative Symbols: MSA, TPX, TDH2A

Protein Name: Thyroid peroxidase

Molekulargewicht: 83 kDa

Gen-ID: 7173

NCBI Accession: NP_000538

UniProt: P07202

Pathways: Thyroid Hormone Synthesis