Thyroperoxidase Antikörper (AA 685-804)

Produktnummer ABIN6940796

Der Maus Monoklonal anti-Thyroperoxidase Antikörper (Klon TPO-1921) (ABIN6940796) detektiert spezifisch Thyroperoxidase in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für Thyroperoxidase Antikörper (AA 685-804) (ABIN6940796)

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser Thyroperoxidase Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Klon: TPO-1921

Produktdetails anti-Thyroperoxidase Antikörper

Bindungsspezifität: AA 685-804

Verwendungszweck: TPO (Thyroid Peroxidase) (Thyroid Marker) Antibody

Spezifität: Thyroperoxidase (TPO) is a 933 amino acid, type I transmembrane glycoprotein that plays a key role in thyroid gland function and autoimmunity. It is present as a dimer on the apical surface of thyroid follicular cells. TPO functions in the iodination of tyrosine residues in thyroglobulin and phenoxy-ester formation between pairs of iodinated tyrosines to generate the thyroid hormones, thyroxine and triiodothyronine. Mutations in this gene are associated with several disorders of thyroid hormonogenesis, including congenital hypothyroidism, congenital goiter, and thyroid hormone organification defect IIA.Malignant thyroid tumors exhibit an anomaly in TPO resulting in lower affinity for anti-TPO. This antibody may aid in the differentiation between benign and malignant thyroid tumors.

Aufreinigung: 200ug/ml of Ab Purified from Bioreactor Concentrate by Protein A/G.

Immunogen: Recombinant fragment of human TPO (around aa 685-804) (Exact sequence is proprietary)

Isotyp: IgG1, kappa

Anwendungsinformationen

Applikationshinweise:

Positive Control: Thyroid Carcinoma.

Known Application: Immunohistochemistry (Formalin-fixed) (1-2 μg/mL for 30 minutes at RT),(Staining of formalin-fixed tissues requires boiling tissue sections in 10 mM citrate buffer, pH 6.0, for 10-20 min followed by cooling at RT for 20 minutes),Optimal dilution for a specific application should be determined.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Konzentration: 200 μg/mL

Buffer: Prepared in 10 mM PBS with 0.05 % BSA & 0.05 % azide.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Lagerung: 4 °C

Informationen zur Lagerung: Antibody with azide - store at 2 to 8°C. Antibody without azide - store at -20 to -80°C. Antibody is stable for 24 months. Non-hazardous. No MSDS required.

Haltbarkeit: 24 months

Details zu Thyroperoxidase

Target: Thyroperoxidase (TPO) (Thyroid Peroxidase (TPO))

Andere Bezeichnung: TPO

Substanzklasse: Viral Protein

Hintergrund:

MSA, TDH2A, Thyroid microsomal antigen, Thyroid peroxidase, Thyroperoxidase, TPO, TPX

Thyroid Carcinoma.

Molekulargewicht: 100kDa

Gen-ID: 7173, 467554

UniProt: P07202

Pathways: Thyroid Hormone Synthesis