GFR Antikörper (Middle Region)

Produktnummer ABIN8109980

Der Kaninchen Polyklonal anti-GFR Antikörper wird verwendet zum Nachweis von GFR in Proben von Human. Er wurde validiert für WB.

Kurzübersicht für GFR Antikörper (Middle Region) (ABIN8109980)

Target: GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser GFR Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-GFR Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: RAPGEF5 Antibody - middle region

Sequenz: GMHRRHTVDE YSPQKKNKAL FHQFSLKENW LQHRGTVTET EEIFCHVYIT

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of Human RPGF5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP75290-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu GFR

Target: GFR (RAPGEF5) (Rap Guanine Nucleotide Exchange Factor (GEF) 5 (RAPGEF5))

Andere Bezeichnung: RAPGEF5

Hintergrund:

Background Information: Members of the RAS (see HRAS, MIM 190020) subfamily of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000 [PubMed 10934204]).[supplied by OMIM, Mar 2008]

Gene Name: Rap guanine nucleotide exchange factor 5

Alternative Symbols: GFR, REPAC, MR-GEF

Protein Name: rap guanine nucleotide exchange factor 5

Molekulargewicht: 48kDa

Gen-ID: 9771

UniProt: Q92565

Pathways: RTK Signalweg, Neurotrophin Signalübertragung, Hepatitis C