PRR5 Antikörper (Middle Region)

Produktnummer ABIN8108998

Dieser Kaninchen Polyklonal Antikörper detektiert spezifisch PRR5 in WB. Es zeigt Reaktivität gegenüber Proben von Human.

Kurzübersicht für PRR5 Antikörper (Middle Region) (ABIN8108998)

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Reaktivität: Human

Wirt: Kaninchen

Klonalität: Polyklonal

Konjugat: Dieser PRR5 Antikörper ist unkonjugiert

Applikation: Western Blotting (WB)

Produktdetails anti-PRR5 Antikörper

Bindungsspezifität: Middle Region

Verwendungszweck: PRR5 Antibody - middle region

Sequenz: TLVQKVVSPY LGTYGLHSSE GPFTHSCILE KRLLRRSRSG DVLAKNPVVR

Homologie: Cow: 86%, Dog: 86%, Horse: 86%, Human: 100%, Mouse: 86%, Pig: 93%, Rabbit: 100%, Rat: 93%

Aufreinigung: Affinity purified

Immunogen: The immunogen is a synthetic peptide directed towards the middle region of human PPR5

Anwendungsinformationen

Applikationshinweise: Optimal working dilution should be determined by the investigator.

Kommentare:

We also sell a specific blocking peptide that can be used in combination with this antibody. You can find the blocking peptide under AAP58943-100UG

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 0.5 mg/mL

Buffer: Purified antibody supplied in 1x PBS buffer with 0.09 % (w/v) sodium azide and 2 % sucrose.

Konservierungsmittel: Sodium azide

Vorsichtsmaßnahmen: This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.

Handhabung: prevent freeze-thaw cycles

Lagerung: 4 °C,-20 °C

Informationen zur Lagerung: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20 °C in small aliquots to prevent freeze-thaw cycles.

Details zu PRR5

Target: PRR5 (Proline Rich 5 (Renal) (PRR5))

Andere Bezeichnung: PRR5

Hintergrund:

Background Information: This gene encodes a protein with a proline-rich domain. This gene is located in a region of chromosome 22 reported to contain a tumor suppressor gene that may be involved in breast and colorectal tumorigenesis. The protein is a component of the mammalian target of rapamycin complex 2 (mTORC2), and it regulates platelet-derived growth factor (PDGF) receptor beta expression and PDGF signaling to Akt and S6K1. Alternative splicing and the use of alternative promoters results in transcripts encoding different isoforms. Read-through transcripts from this gene into the downstream Rho GTPase activating protein 8 (ARHGAP8) gene also exist, which led to the original description of PRR5 and ARHGAP8 being a single gene.

Gene Name: proline rich 5

Alternative Symbols: PP610, PROTOR1, PROTOR-1, FLJ20185k

Protein Name: proline-rich protein 5

Molekulargewicht: 31 kDa

Gen-ID: 55615

UniProt: P85299

Pathways: PI3K-Akt Signalweg