MUC16 Antikörper (AA 1700-2000)

Produktnummer ABIN8093337

Der Maus Monoklonal anti-MUC16 Antikörper (Klon CA125-8893) (ABIN8093337) detektiert spezifisch MUC16 in IHC. Dieser Antikörper reagiert spezifisch mit Proben aus Human.

Kurzübersicht für MUC16 Antikörper (AA 1700-2000) (ABIN8093337)

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Reaktivität: Human

Wirt: Maus

Klonalität: Monoklonal

Konjugat: Dieser MUC16 Antikörper ist unkonjugiert

Applikation: Immunohistochemistry (IHC)

Güteklasse: Carrier-free

Klon: CA125-8893

Produktdetails anti-MUC16 Antikörper

Bindungsspezifität: AA 1700-2000

Verwendungszweck: MUC16 Antibody / CA125 (azide and preservative free)

Immunogen: A recombinant fragment (around amino acids 1700-2000) of human MUC16 protein (exact sequence is proprietary) was used as the immunogen for the Cancer antigen 125 antibody.

Isotyp: IgG2b, kappa

Anwendungsinformationen

Applikationshinweise: Optimal dilution of the Cancer antigen 125 antibody should be determined by the researcher.

Beschränkungen: Nur für Forschungszwecke einsetzbar

Handhabung

Format: Liquid

Konzentration: 1 mg/mL

Buffer: 1 mg/mL in 1X PBS, BSA free, sodium azide free

Konservierungsmittel: Azide free

Lagerung: -20 °C,-80 °C

Informationen zur Lagerung: Cancer antigen 125 antibody with sodium azide - store at 2 to 8oC, antibody without sodium azide - store at -20 to -80oC.

Details zu MUC16

Target: MUC16 (CA125) (Mucin 16, Cell Surface Associated (CA125))

Andere Bezeichnung: MUC16

Hintergrund: Cancer antigen 125 Antibody recognizes Mucin 16 (MUC16), a very high molecular weight transmembrane glycoprotein widely known as CA125 and Ovarian cancer antigen 125. MUC16 is a membrane-associated mucin characterized by extensive O-linked glycosylation, multiple tandem repeat domains, and a large extracellular region that can be proteolytically shed into circulation. Cancer antigen 125 Antibody is useful for detecting MUC16 expression in epithelial and tumor tissues in research applications.

MUC16 antibody, also referred to as CA125 antibody and Mucin-16 antibody in the literature, targets a mucin primarily expressed on the apical surface of epithelial cells lining the female reproductive tract, including endometrium and fallopian tube, as well as in ocular and respiratory epithelium. Under physiologic conditions, MUC16 contributes to epithelial barrier protection, lubrication, and defense against environmental stress. Release of its extracellular domain forms circulating CA125, which serves as a widely used serum biomarker for monitoring ovarian carcinoma.

The MUC16 gene is located on human chromosome 19p13.2 and encodes one of the largest membrane-associated proteins identified. Structurally, the protein contains numerous SEA domains, extensive tandem repeats, a transmembrane region, and a short cytoplasmic tail that participates in intracellular signaling interactions. MUC16 has been shown to bind mesothelin and contribute to tumor cell adhesion and peritoneal dissemination in ovarian cancer models.

Aberrant overexpression of MUC16 is most strongly associated with epithelial ovarian carcinoma and is also observed in subsets of endometrial, pancreatic, breast, lung, and gastrointestinal carcinomas. In histologic sections, MUC16 typically demonstrates apical membranous and cytoplasmic staining in positive epithelial tumor cells. A CA125 antibody is commonly applied in research settings to evaluate epithelial differentiation, tumor origin, and mucin biology. Clone CA125/8893 is a mouse monoclonal antibody developed to target MUC16 in experimental systems.

UniProt: Q8WXI7